Curcumin shows significant therapeutic potential in attenuating autism brain damage induced by prenatal VPA exposure

(Natural News) Curcumin, a compound derived from turmeric, has been linked with the amelioration of chemical-induced autism. A study published in the journal BMC Complementary and Alternative Medicine looked into curcumin’s effects against autism induced by valproic acid (VPA). Valproic acid is a fatty acid used for the treatment of epilepsy in children. Its use...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Publication date: Available online 14 August 2018Source: Journal of Neuroscience MethodsAuthor(s): Matthew S. Binder, Christian J. Hernandez-Zegada, Christian T. Potter, Nolan O. Suzanne, Joaquin N. LugoAbstractAlterations in early-life communicative behaviors are a common feature of neurodevelopmental conditions such as autism and epilepsy. One method of investigating communication in murine models is through analyzing ultrasonic vocalizations. These vocalizations are commonly recorded with either the Avisoft or the Ultravox recording programs. However, since no study has compared whether the systems are equally sensitive...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
We report on 2 brothers, aged 7.6 and 20 years, presenting with cognitive impairment, epilepsy, autistic features, hearing loss, and obesity. Array-CGH analysis demonstrated 2 rare CNVs in both siblings: a paternally inherited microdeletion of ∼145 kb at 3p22.1, disrupting theULK4 gene, and a maternally inherited microduplication of ∼117 kb at Xq21.1 including only theBRWD3 gene. As already described for other recurrent syndromes with variable phenotype, these findings are challenging in genetic counseling because of an evident variable penetrance. We discuss the possible correlations between the clinical phenotype...
Source: Cytogenetic and Genome Research - Category: Genetics & Stem Cells Source Type: research
We report on 2 brothers, aged 7.6 and 20 years, presenting with cognitive impairment, epilepsy, autistic features, hearing loss, and obesity. Array-CGH analysis demonstrated 2 rare CNVs in both siblings: a paternally inherited microdeletion of ∼145 kb at 3p22.1, disrupting theULK4 gene, and a maternally inherited microduplication of ∼117 kb at Xq21.1 including only theBRWD3 gene. As already described for other recurrent syndromes with variable phenotype, these findings are challenging in genetic counseling because of an evident variable penetrance. We discuss the possible correlations between the clinical phenotype...
Source: Cytogenetic and Genome Research - Category: Genetics & Stem Cells Source Type: research
[´╗┐Neuropsychiatric manifestations in Tuberous Sclerosis Complex (TSC): diagnostic guidelines, TAND concept and therapy with mTOR inhibitors´╗┐]. Z Kinder Jugendpsychiatr Psychother. 2018 Aug 06;:1-14 Authors: Waltereit R, Feucht M, de Vries MC, Huemer J, Roessner V, de Vries PJ Abstract Neuropsychiatric manifestations in Tuberous Sclerosis Complex (TSC): diagnostic guidelines, TAND concept and therapy with mTOR inhibitors Abstract. Tuberous sclerosis complex (TSC), albeit a rare autosomal-dominant multisystem disease with an incidence of 1:6,000, is one of the most important monogenetic disorders in ...
Source: Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie - Category: Child Development Tags: Z Kinder Jugendpsychiatr Psychother Source Type: research
Publication date: September 2018Source: Neurophysiologie Clinique, Volume 48, Issue 4Author(s): Pierre-Pascal Lenck-SantiniThe epileptogenic network is not only characterized by seizures but also by an impaired function. Indeed, epilepsy is commonly associated with a variety of behavioral and cognitive deficits that, on top of seizures, can dramatically affect patients. In addition, seizures and interictal activity also occur in non-epileptic syndromes such autistic spectrum disorders, schizophrenia and Alzheimer disease. To understand the mechanisms responsible for such overlap, we will consider the possible involvement o...
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Publication date: 26 July 2018Source: Cell, Volume 174, Issue 3Author(s): A. Jeremy Willsey, Montana T. Morris, Sheng Wang, Helen R. Willsey, Nawei Sun, Nia Teerikorpi, Tierney B. Baum, Gerard Cagney, Kevin J. Bender, Tejal A. Desai, Deepak Srivastava, Graeme W. Davis, Jennifer Doudna, Edward Chang, Vikaas Sohal, Daniel H. Lowenstein, Hao Li, David Agard, Michael J. Keiser, Brian ShoichetAlthough gene discovery in neuropsychiatric disorders, including autism spectrum disorder, intellectual disability, epilepsy, schizophrenia, and Tourette disorder, has accelerated, resulting in a large number of molecular clues, it has pro...
Source: Cell - Category: Cytology Source Type: research
Epilepsy and autism spectrum disorder (ASD) are the common neurological manifestations of tuberous sclerosis complex (TSC). EXIST-3 study has recently demonstrated that everolimus reduces seizures in patients with TSC and refractory epilepsy. Here we report the efficacy and safety of everolimus for treatment-refractory seizures in Japanese patients of EXIST-3, along with the exploratory analysis evaluating the everolimus effect on comorbid ASD symptoms in these patients.
Source: Brain and Development - Category: Neurology Authors: Tags: Original article Source Type: research
ABSTRACT Yawning is a stereotyped physiological behavior that can represent a sign or symptom of several conditions, such as stroke, parakinesia brachialis oscitans, parkinsonism, Parkinson ’ s disease and epilepsy. More rarely, it can occur in patients with intracranial hypertension, brain tumor, multiple sclerosis, migraine, Chiari malformation type I, and amyotrophic lateral sclerosis. Drug-induced yawning is an uncommon clinical condition and yawning in patients with autism or schizophrenia is very rare. The aim of this review is to describe in detail the occurrence of the phenomenon in such conditions, and its &...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
CONCLUSION: A subset of children with ASD can benefit from resective surgery, and for those who are not candidates, a VNS can offer significant improvements in seizure control. PMID: 30032808 [PubMed - in process]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Scientists are finding patterns in symptoms among a handful of people with mutations in HNRNPU.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
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