Curcumin shows significant therapeutic potential in attenuating autism brain damage induced by prenatal VPA exposure

(Natural News) Curcumin, a compound derived from turmeric, has been linked with the amelioration of chemical-induced autism. A study published in the journal BMC Complementary and Alternative Medicine looked into curcumin’s effects against autism induced by valproic acid (VPA). Valproic acid is a fatty acid used for the treatment of epilepsy in children. Its use...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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This report suggests that a diagnosis of Inv-Dup (15) can be suspected during more benign atypical condition with a better outcome than usually reported. PMID: 30991884 [PubMed - as supplied by publisher]
Source: Neurocase - Category: Neurology Authors: Tags: Neurocase Source Type: research
Discussion We have found that, in the human genome, the promoter regions of ID-associated genes are uniquely enriched in MER41 LTRs. More specifically, nine ID-associated genes that are putatively important in cognitive evolution exhibit MER41 LTRs in their promoter regions. As more than 100 families of HERV are integrated into our genome, it was important to determine whether our findings are specific to MER41 and to ID-associated genes, and if so to what extent. Among the 133 families of HERV explored here, MER41 is the only family whose LTRs were found with statistically high frequency in the promoter regions of ID-ass...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusions The Cochrane reviews do not provide clear conclusions regarding the effectiveness of TMS and tDCS against adult chronic pain, although small benefits appear to have been observed. However, the authors point out many biases and important heterogeneities of these studies (30). At the moment, it is not possible to establish useful guidelines on the use of TMS and tDCS in the treatment of pediatric migraine and, in general, for pediatric pain treatment. However, adult studies as well as preliminary pediatric reports show that the application of these techniques is safe, with few side effects, potentially low cost...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Anna Lisa Giuliani1, Merhej Berchan1, Juana M. Sanz2, Angelina Passaro2, Stefano Pizzicotti3, Valentina Vultaggio-Poma1, Alba Clara Sarti1 and Francesco Di Virgilio1* 1Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy 2Medical Science Department, University of Ferrara, Ferrara, Italy 3Laboratory Division of the S. Anna Hospital, University of Ferrara, Ferrara, Italy The P2X7 receptor (P2X7R) is a key pro-inflammatory plasma membrane receptor responsible for NLRP3 inflammasome activation and IL-1β release. Various inflammatory plasma membrane receptors (e.g.,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: Almost one-third of ASD patients in our sample had at least one fGID. The presence of fGID was associated with ID, sleep problems and with behavioral problems (as measured by the prescription of psychotropic drugs). This subsample of ASD patients with fGID deserves particular attention in future research projects, focusing on specific phenotypic characteristics and overlapping biological markers that may underlie both pathologies. Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by impairments in social communication and restricted, repetitive patterns ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Inhibitory Actions of Tropeines on the α3 Glycine Receptor Function Victoria P. San Martín, Carlos F. Burgos, Ana M. Marileo, Cesar O. Lara, Anggelo Sazo, Jorge Fuentealba, Leonardo Guzmán, Patricio A. Castro, Luis G. Aguayo, Gustavo Moraga-Cid* and Gonzalo E. Yévenes* Department of Physiology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile Glycine receptors (GlyRs) are chloride-permeable pentameric ligand-gated ion channels. The inhibitory activity of GlyRs is essential for many physiological processes, such as motor control and respiration. In...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractNeurofibromatosis 1 (NF1) is an autosomal dominant genetic disorder that presents with variable phenotypes as a result of mutations in the neurofibromatosis type 1 (NF1) gene and subsequently, abnormal function of the protein product, neurofibromin. Patients with NF1 are at increased risk for central nervous system (CNS) manifestations including structural, functional, and neoplastic disease. The mechanisms underlying the varied manifestations of NF1 are incompletely understood, but the loss of functional neurofibromin, resulting in sustained activation of the oncoprotein RAS, is responsible for tumorigenesis throu...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
This article provides insights into the roles of the multidisciplinary multisite team and lessons learned from the collaboration, in terms of research as well as training of future researchers and clinicians. In addition, the authors detail the major findings to date, including those related to the identification and measurement of early symptoms of ASD, relationship between seizures and early development, and early biomarkers for epilepsy and developmental delay in infants and young children with TSC. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: American Psychologist - Category: Psychiatry & Psychology Source Type: research
Authors: Pirozzi F, Nelson B, Mirzaa G Abstract Expansion of the human brain, and specifically the neocortex, is among the most remarkable evolutionary processes that correlates with cognitive, emotional, and social abilities. Cortical expansion is determined through a tightly orchestrated process of neural stem cell proliferation, migration, and ongoing organization, synaptogenesis, and apoptosis. Perturbations of each of these intricate steps can lead to abnormalities of brain size in humans, whether small (microcephaly) or large (megalencephaly). Abnormalities of brain growth can be clinically isolated or occur ...
Source: Dialogues in Clinical Neuroscience - Category: Neuroscience Tags: Dialogues Clin Neurosci Source Type: research
This article provides insights into the roles of the multidisciplinary multisite team and lessons learned from the collaboration, in terms of research as well as training of future researchers and clinicians. In addition, the authors detail the major findings to date, including those related to the identification and measurement of early symptoms of ASD, relationship between seizures and early development, and early biomarkers for epilepsy and developmental delay in infants and young children with TSC. (PsycINFO Database Record (c) 2019 APA, all rights reserved). PMID: 30945897 [PubMed - in process]
Source: The American Psychologist - Category: Psychiatry & Psychology Authors: Tags: Am Psychol Source Type: research
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