Curcumin shows significant therapeutic potential in attenuating autism brain damage induced by prenatal VPA exposure

(Natural News) Curcumin, a compound derived from turmeric, has been linked with the amelioration of chemical-induced autism. A study published in the journal BMC Complementary and Alternative Medicine looked into curcumin’s effects against autism induced by valproic acid (VPA). Valproic acid is a fatty acid used for the treatment of epilepsy in children. Its use...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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ConclusionFolate transporter deficiency has a wide range of presenting symptoms. Presentation with slowly progressive atypical symptoms, stable white matter changes in brain MRI that does not fit a specific diagnosis, should raise a high suspicion of FOLR1 mutation, even in absence of seizures. Since folate transporter deficiency is a treatable neurodegenerative disorder, early diagnosis and supplementation with folinic acid is vital.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Three UCLA neuroscientists — Michele Basso, Dr. Peyman Golshani and Daniel Aharoni — received a nearly $3.7 million, three-year grant from the National Institutes of Health for a study that will develop imaging technology that allows the recording of tens of thousands of neurons to better understand how the brain goes aw ry in disease.The grant, part of the National Institutes of Health ’s Brain Research Through Advancing Innovative Neurotechnologies, or BRAIN, Initiative, will support the team ’s work to design, manufacture and test a miniature microscope for measuring brain activity in n...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: Human Mutation - Category: Genetics & Stem Cells Authors: Tags: REVIEW Source Type: research
NBEA is a candidate gene for autism, and de novo variants have been reported in neurodevelopmental disease (NDD) cohorts. However,NBEA has not been rigorously evaluated as a disease gene, and associated phenotypes have not been delineated. We identified 24 de novoNBEA variants in patients with NDD, establishingNBEA as an NDD gene. Most patients had epilepsy with onset in the first few years of life, often characterized by generalized seizure types, including myoclonic and atonic seizures. Our data show a broader phenotypic spectrum than previously described, including a myoclonic ‚Äźastatic epilepsy–like phenotype in...
Source: Annals of Neurology - Category: Neurology Authors: Tags: Brief Communication Source Type: research
Abstract The seizure threshold 2 (SZT2) gene has been shown to confer a low seizure threshold and may enhance epileptogenesis in mice. However, its biological function is still not known. Mutations in SZT2 have been reported in very few patients and features range from mild to moderate intellectual disability without seizures to severe intellectual disability with epileptic encephalopathies with severe developmental delay. Here, we report a six-year-old boy with a novel homozygous mutation in SZT2 gene with intellectual disability, seizures, absent speech and autistic features. We are reporting the first patient w...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
Publication date: Available online 17 October 2018Source: Epilepsy &BehaviorAuthor(s): Jamie K. Capal, Christopher Carosella, Elora Corbin, Paul S. Horn, Rebecca Caine, Patricia Manning-CourtneyAbstractObjectivesThe association between autism spectrum disorder (ASD) and epilepsy is well-known. Abnormalities on electroencephalography (EEG) results have been reported in patients with ASD without a history of seizures. However, little is known about the relationship between abnormalities on EEG results and the core features of ASD. The purpose of the study was to determine the relationship between the presence of epilepsy...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Abstract OBJECTIVES: The association between autism spectrum disorder (ASD) and epilepsy is well-known. Abnormalities on electroencephalography (EEG) results have been reported in patients with ASD without a history of seizures. However, little is known about the relationship between abnormalities on EEG results and the core features of ASD. The purpose of the study was to determine the relationship between the presence of epilepsy and/or abnormalities on EEG results and disease-associated impairments in young children with ASD. METHODS: Data were collected from medical records at Cincinnati Children's Hospit...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
ConclusionsThe findings suggest that the stigma associated with parenting a child with disabilities may be one mechanism that places such parents at risk for poor health. Efforts to alleviate the stigma associated with developmental disorders or mental health problems may have beneficial effects on health of parents of individuals with such conditions.
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 5 October 2018Source: Stem Cell ResearchAuthor(s): Nickesha C. Anderson, Meghan A. Van Zandt, Swechhya Shrestha, Daniel B. Lawrence, Jyoti Gupta, Christopher Y. Chen, Felicia A. Harrsch, Trinithas Boyi, Carolyn E. Dundes, Gloster Aaron, Janice R. Naegele, Laura GrabelAbstractGABAergic interneuron dysfunction has been implicated in temporal lobe epilepsy (TLE), autism, and schizophrenia. Inhibitory interneuron progenitors transplanted into the hippocampus of rodents with TLE provide varying degrees of seizure suppression. We investigated whether human embryonic stem cell (hESC)-derived int...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
An artificial intelligence (AI) algorithm that analyzes whole-brain structural...Read more on AuntMinnie.comRelated Reading: AI helps uncover clues for Alzheimer's disease in MRI data NYMIIS: Next-gen PACS will include 'best-of-breed' AI C-MIMI: AI automatically generates radiology impressions fMRI shows dementia patients' brain response to music DTI-MRI finds abnormal brain connections in autistic kids
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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