Development and characterization of an inducible mouse model for glycogen storage disease type Ib

ConclusionsTM-induced inactivation of G6PT in these mice leads to a phenotype which mimics that of human GSD1b patients. The conditional mice we have generated represent an excellent tool to study the tissue-specific role of theG6PT gene and the mechanism of long-term complications in GSD1b.

http://link.springer.com/10.1007/s10545-018-0211-2

Source: Journal of Inherited Metabolic Disease - July 2, 2018 Category: Internal Medicine Source Type: research