Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome

ConclusionsProteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer ’s disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research

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Publication date: Available online 21 February 2019Source: Advances in Child Development and BehaviorAuthor(s): Angela F. Lukowski, Helen M. Milojevich, Lauren EalesAbstractInfants and children with Down syndrome (DS) can look forward toward bright futures, as individuals with DS are living healthier, more productive lives than ever due to medical advances, opportunities for early and continued intervention, and inclusive education. Despite these advances, infants and children with DS experience challenges in specific domains of cognitive functioning relative to their typically developing (TD) peers. Over the long term, in...
Source: Advances in Child Development and Behavior - Category: Child Development Source Type: research
The effect of meal on blood glucose concentration is a key issue in diabetes mellitus because its estimation could be very useful in therapy decisions. In the case of type 1 diabetes mellitus (T1DM), the therapy based on automatic insulin delivery requires a closed-loop control system to maintain euglycaemia even in the postprandial state. Thus, the mathematical modelling of glucose metabolism is relevant to predict the metabolic state of a patient. Moreover, the eating habits are characteristic of each person, so it is of interest that the mathematical models of meal intake allow to personalise the glycaemic state of the ...
Source: IET Systems Biology - Category: Biology Source Type: research
An MIT-led research team has developed a drug capsule -- about the size of a blueberry -- that could be used to deliver oral doses of insulin, potentially replacing the injections that people with Type 1 diabetes have to give themselves every day. In tests in animals, the researchers showed that ...This is an NSF Multimedia Gallery item.
Source: NSF Multimedia Gallery - Category: Science Source Type: video
Authors: Kirac D, Yagcioglu Yassa O, Gezmis H, Mayda Domac SF, Altunok EC, Genc E Abstract Obstructive sleep apnea syndrome (OSAS) is a highly prevalent disorder which results in markedly reduced (hypopnea) or absent (apnea) airflow at the nose/mouth. Since vitamin D deficiency has found in an association with some disorders it is thought to be related with OSAS progression. The aim of this study is to investigate the association between VDR, VDBP mutations, vitamin D level and some environmental risk factors with OSAS. Fifty individuals who were diagnosed as OSAS were selected as patients, 50 healthy volunteers wi...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
This paper reviews the pharmacological options which are currently available for treatment of Alzheimer disease, as well as potential new agents and approaches under investigation.U.S. Pharmacist
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pharmacist Journal Article Source Type: news
To evaluate the complication rate in peri-menopausal women undergoing myomectomy versus hysterectomy for the treatment of uterine leiomyoma.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
(MedPage Today) -- Randomized analysis lacked a comparator group, however
Source: MedPage Today Endocrinology - Category: Endocrinology Source Type: news
AbstractPurpose of ReviewMODY6 due to mutations in the gene NEUROD1 is very rare, and details on its clinical manifestation and pathogenesis are scarce. In this review, we have summarized all reported cases of MODY6 diagnosed by genetic testing, and examined their clinical features in detail.Recent FindingsMODY6 is a low penetrant MODY, suggesting that development of the disease is affected by genetic modifying factors, environmental factors, and/or the effects of interactions of genetic and environmental factors, as is the case with MODY5. Furthermore, while patients with MODY6 can usually achieve good glycemic control wi...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
BOSTON (CBS) – Too busy to exercise during the day? Australian researchers say you may want to consider a 30-minute intense evening workout instead because working out before bed does not disrupt sleep and may even suppress appetite. Researchers took 11 middle-aged men and had them perform high-intensity cycling for six 1-minute sprints with four minutes of rest in between at different times of the day. (Photo by Justin Sullivan/Getty Images) They found that when the men worked out between 7 and 9 p.m., their subsequent sleep was not negatively impacted and that both afternoon and evening exercise suppressed a hormon...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Dr. Mallika Marshall Exercise Source Type: news
CONCLUSIONS: Proteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer's disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. PMID: 29968150 [PubMed - as supplied by publisher]
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Sleep Breath Source Type: research
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