Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome

ConclusionsProteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer ’s disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research

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Publication date: 20 October 2018Source: New Scientist, Volume 240, Issue 3200Author(s): My husband is a lark and I am an owl when it comes to our attitudes to bedtime. This leads to discussions about the ideal time to go to bed. He is convinced that the best sleep happens before midnight, while I believe that no matter when you fall asleep, you are advised to get 8 hours and whether it starts before midnight or after has no relevance to the quality of your sleep. Who is right?
Source: New Scientist - Category: Science Source Type: research
Conclusions/interpretation: Circulating Pro-NT is not independently associated with GDM, but is with HOMA-IR, creatinine, and FFA even after adjustment for pregnancy status.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionThese findings suggest that LTP-like cortical plasticity may represent a neurophysiological surrogate of memory in AD patients by evaluating the weight of pathological changes responsible for cognitive dysfunction.
Source: Brain Stimulation - Category: Neurology Source Type: research
Authors: Sharif K, Watad A, Coplan L, Amital H, Shoenfeld Y, Afek A Abstract INTRODUCTION: Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by the destruction of insulin-producing β-cells of the pancreas. The current paradigm in this disease's etiopathogenesis points toward the interplay of genetic and environmental factors. Among the environmental variables, dietary factors, intestinal microbiota, toxins, and psychological stress have been implicated in disease onset. Areas covered: This review aims to investigate the relationship between psychological stress and T1DM by presenting evidence ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Publication date: Available online 21 October 2018Source: SteroidsAuthor(s): Laurie S. Conklin, Peter A. Merkel, Lauren M. Pachman, Hemang Parikh, Shefa Tawalbeh, Jesse M. Damsker, David D. Cuthbertson, Gabrielle A. Morgan, Paul A. Monach, Yetrib Hathout, Kanneboyina Nagaraju, John van den Anker, Carol A. McAlear, Eric P. HoffmanAbstractGlucocorticoids are standard of care for many chronic inflammatory conditions, including juvenile dermatomyositis (JDM) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We sought to define pharmacodynamic biomarkers of therapeutic efficacy and safety concerns of ...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 October 2018Source: Journal of Herbal MedicineAuthor(s): Ahmad Saedisomeolia, Motahereh Makhdoomi Arzati, Mina Abdolahi, Mohsen Sedighiyan, Alejandra Rangel, Gerald Muench, Meysam Zarezadeh, Arash Jafarieh, Niyaz Mohammadzadeh HonarvarAbstractDiabetes mellitus is considered a metabolic disorder characterized by high blood sugar. Active disease is associated with low grade chronic inflammation resulting from the enhanced release of inflammatory mediators such as interleukin (IL)-1 β, IL-6, induced nitric oxide synthase, and cyclooxygenase-2 enzymes that lead to insulin resistance a...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
What do measles, tuberculosis, and grains have in common? For that matter, what do anthrax, influenza, and brucellosis also share in common with grains? All the conditions listed are examples of zoonoses, i.e., diseases contracted by humans from animals. When humans first invited domesticated grazing creatures–cows, sheep, goats–into our huts, adobe homes, or caves, often sleeping in the same room, using them for milk or food, we acquired many of their diseases. These diseases were unknown prior to the human domestication of grazing ruminants. The process of animal domestication changed the course of human civi...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates gluten gluten-free grain-free grains tuberculosis wheat belly zoonoses Source Type: blogs
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity. RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes https://www.fightaging.org/archives/...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: In selected cases, OA maybe considered as an alternative for the OSAS treatment. PMID: 30341264 [PubMed - as supplied by publisher]
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
CONCLUSIONS: Proteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer's disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. PMID: 29968150 [PubMed - as supplied by publisher]
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Sleep Breath Source Type: research
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