Request for Proposals: Blepharospasm/Meige Research

Request for Proposals: Blepharospasm/Meige Research • Funds up to $150,000 are available for support of research directly related to blepharospasm or Meige's Syndrome, both forms of cranial dystonia • M.D. or Ph.D. required for principal investigator • Non-U.S. citizens, working at institutions abroad are also eligible to apply for a research grant • Research proposals must relate specifically to benign essential blepharospasm and Meige to include new treatments, pathophysiology and genetics, photophobia and dry eye. • If a grant is awarded, we expect a semiannual progress report • Deadline to apply is August 31 each year. •Grant guidelines and a listing of previous grants may be downloaded from the foundation's website or obtained from: Benign Essential Blepharospasm Research Foundation, Inc. P.O. Box 12468 Beaumont, TX 77726-2468 Tel: (409) 832-0788 Fax: (409) 832-0890 E-mail: bebrf@blepharospasm.org
Source: ScanGrants feed - Category: Research Authors: Source Type: funding

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An artificial intelligence-based deep learning platform, DystoniaNet, diagnosed the neurological disorder from MRI scans with close to 99% accuracy, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
In conclusion, we found that different types of OT and orthostatic myoclonus were diagnosed by electrophysiological evaluation and neuroimaging tools even if they showed the same symptoms as “shaky leg.” In addition, it is possible to roughly estimate the response to med ication according to the type of OT and the cause. To clarify the pathophysiology of OT, a large number of longitudinal cohort studies and detailed neuroimaging and electrophysiological evaluations are needed.Neurodegener Dis
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
In conclusion, we found that different types of OT and orthostatic myoclonus were diagnosed by electrophysiological evaluation and neuroimaging tools even if they showed the same symptoms as "shaky leg." In addition, it is possible to roughly estimate the response to medication according to the type of OT and the cause. To clarify the pathophysiology of OT, a large number of longitudinal cohort studies and detailed neuroimaging and electrophysiological evaluations are needed. PMID: 32911473 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research
AbstractComputed tomography (CT) scan of the cervical spine and clinical aspect of a 42 ‐year‐old female followed for 5 years for ankylosing spondylitis presenting with a history of chronic cervical dystonia leading to a neglected fixed head rotation (Figure 1A). Axial CT‐MIP (maximum intensity projection) showed right rotatory dislocation of C1 over C2 with 3,5mm anterior displa cement of the atlas realizing the equivalent of a Type 2 dislocation according to Fielding and Hawkins classification (Figure 1B).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: CLINICAL IMAGE Source Type: research
Conclusion: Our results do not provide evidence for a role of MRI of the cervical spine in the routine work-up of patients with cervical dystonia in the absence of specific clinical signs or symptoms.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study showed that bilateral STN DBS results in a very significant improvement in cervical dystonia with no mental worsening and suggests that STN DBS may be an alternative to GPi DBS for treating primary cervical dystonia.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
AbstractBiallelic variants inPOLR3A cause 4H leukodystrophy, characterized by hypomyelination in combination with cerebellar and pyramidal signs and variable non-neurological manifestations. Basal ganglia are spared in 4H leukodystrophy, and dystonia is not prominent. Three patients with variants inPOLR3A, an atypical presentation with dystonia, and MR involvement of putamen and caudate nucleus (striatum) and red nucleus have previously been reported. Genetic, clinical findings and 18 MRI scans from nine patients with homozygous or compound heterozygousPOLR3A variants and predominant striatal changes were retrospectively r...
Source: Neurogenetics - Category: Genetics & Stem Cells Source Type: research
Conclusions: Our investigation suggests that patients with CD show reduced GFC in brain regions of the M1-SMA motor network and provides further insights into the pathophysiology of CD. GFC values in the right precentral gyrus and right SMA may be used as potential biomarkers to recognize the patients from the controls.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the treatment of multiple neurological and psychiatric disorders. However, the structure of CM is invisible on the standard T1- and T2-weighted (T1w and T2w) magnetic resonance images, which hamper it as a direct DBS target for clinical applications. The purpose of the current study is to demonstrate the use of quantitative susceptibility mapping (QSM) technique to image the CM within the thalamic region. Twelve patients with Parkinson’s dise...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
We report a case of idiopathic cervical dystonia that was treated by computed tomography–guided injection of botulinum toxin into multiple deep muscles. Based on clinical presentation of combined torticollis and retrocollis, and needle electromyography results, botulinum toxin was injected under electromyography guidance. This treatment resulted in no improvement. Subsequently, target muscles were identified using 18F-fludeoxyglucose fusion positron emission tomography/computed tomography. botulinum toxin was injected into the hypermetabolic muscles guided by computed tomography. This injection successfully relieved ...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Case Report Source Type: research
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