MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis; mutant mice challenging old paradigms.

In conclusion, our findings challenge two dogmas of the hormonal regulation of male fertility: (1) high ITT concentration is not necessary for spermatogenesis, and (2) strong FSH stimulation can maintain spermatogenesis without T. These findings have clinical relevance for the development of hormonal male contraception and for the treatment of idiopathic oligozoospermia. PMID: 29959220 [PubMed - as supplied by publisher]
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research