Cardiac hypertrophy in sarcopenic obese C57BL/6J mice is independent of Akt/mTOR cellular signaling.

CONCLUSION: Cardiac hypertrophy in SO is likely pathogenic as evidenced by the alterations in MAPK and AMPK protein content and lack of activation in the Akt/mTOR pathway.
PMID: 29958999 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - June 26, 2018 Category: Geriatrics Authors: Perry RA, Brown LA, Haynie WS, Brown JL, Rosa-Caldwell ME, Lee DE, Greene NP, Washington TA Tags: Exp Gerontol Source Type: research