Retinoblastoma: The importance of early diagnosis.

CONCLUSIONS: This analysis included 58 eyes. There are no previous studies in our community and there are few series so numerous throughout the country. Based on non-standardised treatment, the most appropriate is chosen according to the characteristics of the tumour. The multidisciplinary management, formed by ophthalmology, paediatric oncology, radiotherapy, and radiophysical oncology, is fundamental for the selection of the most appropriate treatment. Chemo-reduction, along with consolidation treatments, offers encouraging results in the control of these tumours, especially in those of less severity. Enucleation continues to be the method of choice in the most advanced staging with vitreous involvement, with the importance of early diagnosis being highlighted. PMID: 29954624 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

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Publication date: Available online 24 May 2021Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Carol L. Shields, Philip W. Dockery, Antonio Yaghy, Emily R. Duffner, Hannah J. Levin, Olivia S. Taylor, Zaynab Sajjadi, Sara E. Lally, Jerry A. Shields, Robert Rosenwasser, Stavropoula Tjoumakaris, Pascal Jabbour
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
Abstract Retinoblastomas represent 6% of all malignant tumors in children under 5 years old, which untreated lead to blindness in the affected eye and death due to metastases. The main symptoms are leukocoria and strabismus, which if possible, always necessitate a clarification within 1 week for exclusion of a retinoblastoma. The most frequent differential diagnoses are Coats' disease and persistent fetal vasculature (PFV) as well as other intraocular tumors, in particular astrocytomas. Systemic chemotherapy, if necessary in combination with laser hyperthermia, local chemotherapy and brachytherapy are the most imp...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
ConclusionsOur demographic and basic clinical data for advanced RB are comparable to other similar reports. The tumor growth pattern correlates well with the type of seeding observed in enucleated globes with RB. Less tumor differentiation is a relative risk of massive choroidal invasion. It is advocated to implement the AJCC 8th edition by ocular pathologists worldwide aiming to histopathologically classify the RB tumor in cases for selective adjuvant chemotherapy.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Conclusion: Our experience suggests that IAC is a safe and effective treatment for patients with ICRB group B, C, D, and some group E retinoblastoma. Careful patient selection and experienced surgeons are critical for achieving the best treatment outcome.
Source: Asia-Pacific Journal of Ophthalmology - Category: Opthalmology Tags: Original Clinical Study Source Type: research
We report 2 cases of iris heterochromia secondary to profound iris stromal depigmentation following intravitreal melphalan and topotecan injections.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
Conclusion: The pathophysiology of choroidal ischemia is not well understood, but the fortuitous watershed zone preservation in this case could represent uneven distribution of the chemotherapeutic drug, resulting in partial chemo-dilution of the medication in the watershed region, which represents the final downstream overlapping choroidal perfusion from both medial and lateral posterior ciliary arteries.Ocul Oncol Pathol
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
Publication date: Available online 1 August 2018Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Ido D. Fabian, Andrew W. Stacey, Zishan Naeem, Zerrin Onadim, Tanzina Chowdhury, Catriona Duncan, Mandeep S. Sagoo, M. Ashwin ReddyPurposeTo report the long-term strabismus rate in salvaged retinoblastoma (Rb) patients and investigate possible risk factors leading to strabismus.MethodsThe medical records of patients with Rb presenting at a single institution over a 9-year period were reviewed retrospectively with regard to ocular alignment outcomes after long-term follow-up.ResultsA t...
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
The common presenting features of intraocular retinoblastoma (RB) include leukocoria (L), strabismus (S), and inflammation (I). Leukocoria has been associated with poorer ocular survival. Exotropia has been shown to be more common than expected in infantile strabismus. The impact of the combination of L and S presenting together has not been assessed. The need for enucleation at presentation and the use of adjuvant chemotherapy post-enucleation are recognised indicators of advanced disease.
Source: Journal of AAPOS - Category: Opthalmology Authors: Tags: Poster Source Type: research
Publication date: June 2018Source: Journal of American Association for Pediatric Ophthalmology and Strabismus, Volume 22, Issue 3Author(s): Raksha Rao, Santosh G. Honavar, Kaustubh Mulay, Vijay Anand P. ReddyDiffuse anterior retinoblastoma is an infrequent presentation in which the tumor is confined to the anterior segment, and there is no retinal mass. An 18-month-old Asian Indian boy presented with white spots in the left eye. There were extensive anterior segment seeds without a retinal tumor. Fine-needle aspiration biopsy confirmed the diagnosis of retinoblastoma, and the patient received intravenous chemotherapy with ...
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
ConclusionsRetinoblastoma is often diagnosed at an advanced stage. With the development of systemic and local chemotherapy, the number of eyes with advanced retinoblastoma preserved by conservative therapy has been increasing.
Source: Japanese Journal of Ophthalmology - Category: Opthalmology Source Type: research
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