The Pharmacogenomics of Asthma beyond its Endotypes.

The Pharmacogenomics of Asthma beyond its Endotypes.
Curr Drug Metab. 2018 Jun 28;:
Authors: Meng S, Chen S, Tao A
Abstract
Asthma is a heterogeneous disease that consists of different phenotypes and endotypes, driven by different mechanistic pathways. An increasing number of genetic loci and single-nucleotide polymorphisms have been associated with therapeutic responses to asthma drugs. The purpose of this review is to focus on certain susceptibility genes, gene variants and typical therapeutic drugs of the glucocorticoid, leukotriene, histamine, and β2-adrenergic receptor pathways related to asthma. Pharmacogenomics can help us better understand the genetic basis of drug responses and better define new therapeutic targets to improve treatment effectiveness.
PMID: 29956621 [PubMed - as supplied by publisher]

Source: Current Drug Metabolism - June 28, 2018 Category: Drugs & Pharmacology Authors: Meng S, Chen S, Tao A Tags: Curr Drug Metab Source Type: research