White matter hyperintensities in myotonic dystrophy type 2: not always another expression of the disease.

We report herein the case of a 38-year old woman, with the rare co-existence of DM2 and MS and argue about the challenging differential diagnosis if CNS involvement is present in DM2 patients. Thus, is it another expression of a multisystem disorder or an unfortunate pure coincidence?
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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CONCLUSION: For better therapeutic outcome, proper selection of drug moiety with its appropriate administration is the major requisite. With the advent of nanotechnology, the development of nanocarrier for dermatologic application has been successfully demonstrated in positioning the systemically administrated drug into topical targeted delivery. In a nutshell, to achieve successful treatment strategies towards psoriasis, there is a need to focus on the development of stable, non-toxic nanocarrier for topical delivery. Inclusion of the existing orally administered drug moiety into nanocarriers for topical delivery is propo...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Resumo Este artigo possui o objetivo de realizar uma reflex ão teórica sobre os fundamentos histórico-sociais da pandemia de COVID-19. A partir da matriz teórica materialista histórica, evoca-se as categorias da “ mundializa ção do capital ” , “ capital-imperialismo ” , “ compress ão espaço-tempo ” e “ crise estrutural do capital ” tra çando um percurso que ultrapassa os limites das Ciências da Saúde a fim de entender a saúde global, da qual a pandemia de COVID-19 é expressã...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
In this study, we investigated the expressions of chemokines and their receptors during adipogenesis and inflammation in primary cultured orbital fibroblasts from patients with GO. METHODS: The messenger RNA (mRNA) expression levels of chemokines were compared between GO (n = 6) and non-GO (n = 5) orbital tissues by real-time polymerase chain reaction. After adipogenesis was induced in primary cultured orbital fibroblasts from patients with GO (n =5) and following stimulation with interleukin (IL)-1β and tumor necrosis factor (TNF)-α, the mRNA expression levels of chemokines and their receptors were analyzed...
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Publication date: Available online 4 June 2020Source: NeuroImage: ClinicalAuthor(s): Sandra González-Villá, Arnau Oliver, Yuankai Huo, Xavier Lladó, Bennett A. Landman
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Condition:   Fuchs' Endothelial Dystrophy Interventions:   Procedure: Phaco-DSAEK;   Procedure: Phaco-DMEK Sponsor:   University of Aarhus Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 4 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Kevin Yan, Chakrapani Balijepalli, Kamal Desai, Lakshmi Gullapalli, Eric Druyts
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 4 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Jan Kolcava, Jan Kocica, Monika Hulova, Ladislav Dusek, Magda Horakova, Milos Kerkovsky, Jakub Stulik, Marek Dostal, Matyas Kuhn, Eva Vlckova, Josef Bednarik, Yvonne Benesova
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: August 2020Source: Multiple Sclerosis and Related Disorders, Volume 43Author(s): Zuhal Abasıyanık, Asiye Tuba Özdoğar, Özge Sağıcı, Turhan Kahraman, Cavid Baba, Özge Ertekin, Serkan Özakbaş
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
In this study, we selected semaphorin-3A (Sema3A), semaphorin-7A (Sema7A), and their receptors to determine the possible relationship between these molecules and multiple sclerosis (MS). METHOD: We measured the gene expression of Sema3A, Sema7A, neuropilin-1 (NP-1), plexin-C1, and β1 integrin in the blood samples of relapsing-remitting multiple sclerosis (RRMS) patients, treated with high-dose interferon-β1a (IFN-β1a), low-dose IFN-β1a, IFN-β1b, and glatiramer acetate (GA) via quantitative real-time polymerase chain reaction (qRT-PCR) assay, and then, compared the results of treatment-naive pat...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
We report herein the case of a 38-year old woman, with the rare co-existence of DM2 and MS and argue about the challenging differential diagnosis if CNS involvement is present in DM2 patients. Thus, is it another expression of a multisystem disorder or an unfortunate pure coincidence?
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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