Latest Updates in Dengue Fever Therapeutics: Natural, Marine, and Synthetic Drugs.

Latest Updates in Dengue Fever Therapeutics: Natural, Marine, and Synthetic Drugs.
Curr Med Chem. 2018 Jun 29;:
Authors: Hosseini S, Munoz-Soto RB, Oliva-Ramirez J, Vazquez-Villegas P, Aghamohammadi N, Rodriguez-Garcia A, Martinez-Chapa SO
Abstract
In this paper, we review the history of Dengue, the mechanism of infection, the molecular characteristics and components of Dengue, the mechanism of entry to the target cells, cyclization of the genome and replication process, as well as translation of the proteins for virus assembly. The major emphasis of this work is on natural products and plant extracts, which were used for as palliative or adjuvant treatment of Dengue. This review article also summarizes latest findings in regards to the marine products as effective drugs to target different symptoms of Dengue. Furthermore, an update on synthetic drugs for treating Dengue is provided in this review. As a novel alternative, we describe monoclonal antibody therapy for Dengue management and treatment.
PMID: 29956614 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - June 29, 2018 Category: Chemistry Authors: Hosseini S, Munoz-Soto RB, Oliva-Ramirez J, Vazquez-Villegas P, Aghamohammadi N, Rodriguez-Garcia A, Martinez-Chapa SO Tags: Curr Med Chem Source Type: research