Haplotype ‐based association of Vascular Endothelial Growth Factor gene polymorphisms with urothelial bladder cancer risk in Tunisian population

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

Related Links:

Conclusion: MDM2 amplification was most commonly associated with liposarcoma. Concomitant alterations in additional genes such as CDK4 amplification and TP53 mutations, along with variable responses to targeted therapies including MDM2 inhibitors, suggest that further combinational studies are needed to target this population. PMID: 30237864 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions: We demonstrated a strong association between the proportion of circulating CD8+ILT2+ T cells and NMIBC risk of recurrence. Gain in prediction was substantial. If externally validated, such immunological marker could be integrated to predict NMIBC recurrence. PMID: 30237859 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Krajewski W, Halska U, Poletajew S, Piszczek R, Bieżyński B, Matyjasek M, Tukiendorf A, Menzel F, Mazur M, Rymaszewska J, Zdrojowy R Abstract The standard of care in non-muscle invasive bladder cancer consists of transurethral tumor resection. The aim of this study was to evaluate the influence of transurethral resection of bladder tumor (TURB) on the patients' self-reported depression, anxiety, sexual satisfaction, and erectile dysfunction. Psychological condition of 252 male patients who underwent TURB was prospectively evaluated. The Hospital Anxiety and Depression Scale (HADS), simplified Internation...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 17 September 2018Source: Sensors and Actuators B: ChemicalAuthor(s): Seong-Eun Kim, Young Joo Kim, Sunga Song, Kook-Nyung Lee, Woo Kyeong SeongAbstractBladder cancer is one of the tumors associated with the highest mortality rate. It is clinically characterized by high recurrent rates and poor prognosis once tumors invade the lamina propia. Nevertheless, current diagnostic techniques such as cystoscopy and cytology are invasive, time-consuming, and expensive. To address these challenges, we developed an electrochemical enzyme-linked immunosorbent assay (eELISA) platform on indium tin oxid...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
ConclusionsPrior or synchronous second malignancies are common at diagnosis of NSCLC. The sites reflect the high proportion of smokers in the population. The earlier stage of NSCLC with a second malignancy might be attributed to chance finding of NSCLC during follow-up. The second malignancy does not affect OS of NSCLC. Therefore, the exclusion of patients with second malignancies from NSCLC trials should be reconsidered.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 September 2018Source: Urology PracticeAuthor(s): Talia Stark, Jonathan Shoag, Joseph Nicolas, Neal Patel, Benjamin Taylor, Douglas S. ScherrAbstractPurposeContemporary data on bladder cancer care in the United States (US) is lacking. Here, we use nationally representative data to characterize outpatient bladder cancer care in the US and identify potential areas for quality improvement.Materials and MethodsThe National Ambulatory Medical Care Survey (NAMCS), conducted annually by the Centers for Disease Control and Prevention, is designed to generate weighted estimates of national ambul...
Source: Urology Practice - Category: Urology & Nephrology Source Type: research
UPK1B promotes the invasion and metastasis of bladder cancer via regulating the Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci. 2018 Sep;22(17):5471-5480 Authors: Wang FH, Ma XJ, Xu D, Luo J Abstract OBJECTIVE: The aim of this study was to investigate the expression of UPK1B in bladder cancer (BCa), and to further explore the correlation between UPK1B expression and pathological parameters as well as the prognosis of BCa. PATIENTS AND METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of UPK1B in 92 pairs of BCa tissues and adjacent normal t...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Fujimoto Chiho Ohbayashi The nucleus accumbens-associated protein 1 (NACC1) is a transcription factor constitutively expressed in the urothelium, where it regulates cell growth, senescence, autophagy, and epithelial-mesenchymal transition. microRNA (miRNA) constitutes a class of small non-coding RNAs which are involved in cell proliferation, differentiation, and progression of tumors. miRNAs and their target molecules are utilized for molecular diagnosis of urothelial carcinoma. NACC1 is one of several putative target molecules of miR-331-3p, and is associated with cell proliferation in cancers such as prostate and ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research
CONCLUSIONS: CDK4/6 inhibitors, alone or in combination, are a novel therapeutic strategy for advanced BC patients previously classified as unfit for current treatment options. PMID: 30242024 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
More News: Bladder Cancer | Cancer | Cancer & Oncology | Genetics | Laboratory Medicine | Tunisia Health