Haplotype ‐based association of Vascular Endothelial Growth Factor gene polymorphisms with urothelial bladder cancer risk in Tunisian population
Journal of Clinical Laboratory Analysis, EarlyView.
TURBT with fluorescent light source using oral 5-ALA is well tolerated in non –muscle-invasive bladder cancer.
Jeanny B. Aragon-Ching, MD, FACP, explains reliable molecular markers that can help identify high-risk muscle-invasive bladder cancer patients who should receive neoadjuvant therapy. Author: obr Added: 07/18/2018
Gary D. Steinberg, MD, explains whether FGFR inhibitors in metastatic bladder cancer have the potential to be practice changing at ASCO 2018. Author: obr Added: 07/18/2018
Jeanny B. Aragon-Ching, MD, FACP, discusses how new guidelines have changed the treatment of advanced metastatic bladder cancer at ASCO 2018. Author: obr Added: 07/18/2018
In conclusion, targeting the SDF‑1/CXCR4/β‑catenin axis may be a potential therapeutic target for suppressing BCa progression. PMID: 30015971 [PubMed - as supplied by publisher]
A novel regulatory circuit of miR‑152 and DNMT1 in human bladder cancer. Oncol Rep. 2018 Jul 10;: Authors: Zhang H, Qi D, Li J, Peng T, Yang L, Yuan J, Zhang Y, Hu Y, Su J, Que B, Li M, Zhou G, Chen Y, Zhang W, Ji W Abstract Downregulation of microRNA‑152 (miR‑152) has been observed in various types of human malignancies, including Bladder cancer (BC). However, the role of miR‑152 in the development and progression of BC is still unclear. In our previous study, we identified a functional crosstalk between miR‑152 and DNA methyltransferase 1 (DNMT1) involved in Nis‑induced malignant tra...
In conclusion, Elk1 inhibition induced thyroid cancer cell apoptosis and restrained their proliferation by regulating Egr‑1/PTEN, indicating a potential role for Elk1 in thyroid cancer treatment. PMID: 30015900 [PubMed - as supplied by publisher]
Patients with muscle-invasive bladder cancer who underwent trimodal therapy had significantly poorer survival than those who underwent radical cystectomy alone.
In this report, we analysed the effect of chemotherapy on immune cell subsets of 40 patients with advanced bladder cancer. We found that chemotherapy has a positive effect on immune effector T cells, whereas an opposite, diminishing effect was observed for immune-suppressive regulatory T cells. We conclude that chemotherapy reinforces the antitumour immune response in bladder cancer patients.
Publication date: Available online 17 July 2018Source: European UrologyAuthor(s): Valeria Panebianco, Jelle Barentsz, Yoshifumi Narumi, James Catto, on behalf of the VI-RADS authors