Haplotype ‐based association of Vascular Endothelial Growth Factor gene polymorphisms with urothelial bladder cancer risk in Tunisian population

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

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AbstractBladder cancer is the fourth most common cancer in men and fifth most common overall. The use of next-generation sequencing (NGS) approaches is crucial to precisely characterize the molecular defects of tumors, and this information could be combined with other clinical data, such as tumor histology and TNM staging, with the goal of precise tumor classification. In many settings, targeted NGS is evaluated in patients with first- and second-line metastatic cancer. Yet, in the decade to come we anticipate increased application of precision oncology at all stages of bladder cancer with the aim of customizing cancer tre...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 10 November 2018Source: Academic RadiologyAuthor(s): Kenny H. Cha, Lubomir M. Hadjiiski, PhD, Richard H. Cohan, MD, Heang-Ping Chan, PhD, Elaine M. Caoili, MD, Matthew Davenport, MD, Ravi K. Samala, PhD, Alon Z. Weizer, MD, Ajjai Alva, MD, Galina Kirova-Nedyalkova, MD, PhD, Kimberly Shampain, MD, Nathaniel Meyer, MD, Daniel Barkmeier, MD, PhD, Sean Woolen, MD, Prasad R. Shankar, MD, Isaac R. Francis, MD, Phillip Palmbos, MDRationale and ObjectivesTo evaluate whether a computed tomography (CT)-based computerized decision-support system for muscle-invasive bladder cancer treatment response ...
Source: Academic Radiology - Category: Radiology Source Type: research
Authors: Kratzik C, Dorudi S, Schatzl M, Sinzinger H Abstract OBJECTIVE: The introduction of the prostate specific membrane antigen (PSMA) offers the possibility to discover prostate cancer recurrences being frequently so small that they cannot be detected by conventional imaging modalities, such as magnetic resonance or computed tomography. SUBJECTS AND METHODS: A 78 years old patient after radical prostatectomy and lymphadenectomy suffered from recurrence of the disease and galium-68-PSMA (68Ga-PSMA) showed a single hot spot. Therefore, the first time in this indication in Austria radioguided surgery was perf...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
This study assessed a national healthcare intervention launched in Sweden in 2015 to reduce the time between macroscopic haematuria, diagnosis and treatment of urinary tract cancer. METHODS: The outcome of the first 11 months was evaluated in 1697 individuals referred to a standardized care pathway for urinary tract cancer compared with 174 patients with conventionally diagnosed urothelial carcinoma. RESULTS: Among the referred individuals, 317 (19%) were diagnosed with cancer, 1034 (61%) had a benign diagnosis and 345 (20%) had a negative evaluation. Bladder cancer was the most common malignant diagnosis [262/317 ...
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
ConclusionsOur data unprecedently showed that HIC1 was responsible for the inhibition of proliferation, migration, and invasion of BCa via the YAP signaling pathway. These findings suggested that therapeutic strategies regulating HIC1 expression might provide effective treatments for BCa.
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
ConclusionsOver the past two decades, gene therapy has evolved into a powerful tool in our fight against cancer. After overcoming the initial barriers associated with gene delivery to the bladder, we have made significant strides forward in developing this novel therapeutic strategy for the treatment of this inherently resistant disease state. Our results to date are very encouraging; however, much work lies ahead to better understand and optimize this novel approach for treating non-muscle invasive bladder.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
To determine the rate and determinants of neoadjuvant chemotherapy non-completion in patients with muscle-invasive bladder cancer.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Authors: Kato T, Nakayama R, Haba T, Kawaguchi M, Komiya A, Koike H Abstract Segmental ureterectomy (SU) represents a promising alternative for the treatment of upper tract urothelial carcinomas (UTUCs) as it is a less invasive procedure and guarantees the preservation of renal units. The present study evaluated oncological outcomes and renal functions following SU when compared with radical nephroureterectomy (RNU). A total of 26 patients with UTUCs who underwent SU (n=12) or RNU (n=14) were retrospectively evaluated. SU was performed in patients with clinically unifocal disease. In the SU group, the following sur...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Zhang H, Jiang M, Liu Q, Han Z, Zhao Y, Ji S Abstract MicroRNA-145-5p (miR-145-5p) is found to be involved in tumor development and progression. However, there are few studies on the effects of miR-145-5p on bladder cancer (BC). The role of miR-145-5p in BC was predicted by analysis of cell proliferation and migration in this study. The miR-145-5p and transgelin-2 (TAGLN2) expressions were evaluated via reverse transcription-quantitative PCR (RT-qPCR) or western blot analysis. The MTT and Transwell assay assessed cell proliferation and migration. TAGLN2 targeted to miR-145-5p was determined using luciferas...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
ConclusionAn SBRT boost dose of 30Gy can be delivered without compromising QAUANTEC OAR limits. The use of SBRT increases TCP values regardless of input parameters.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
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