Glutathione S-transferases (GSTs) polymorphism could be an early marker in the development of PCOS: an insight from non-obese and non-insulin resistant adolescents.

CONCLUSIONS: PCOS girls exhibited high free radicals production together with unchanged antioxidant enzymatic capacity, independently from obesity and insulin resistance. Based on associations between oxidative stress parameters and testosterone, DHEAS and androstenedione, it can be suggested that increased free radicals production, probably as a consequence of hyperandrogenemia is an early event in the development of PCOS. PMID: 29952411 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29952411?dopt=Abstract

Source: Endokrynologia Polska - June 28, 2018 Category: Endocrinology Authors: Savic-Radojevic A, Mazibrada I, Djukic T, Stankovic ZB, Pljesa-Ercegovac M, Sedlecky K, Bjekic-Macut J, Simic T, Mastorakos G, Macut D Tags: Endokrynol Pol Source Type: research