Total and high molecular weight adiponectin levels and prediction of insulin resistance.

Total and high molecular weight adiponectin levels and prediction of insulin resistance. Endokrynol Pol. 2018 Jun 28;: Authors: Horakova D, Stepanek L, Nagelova R, Pastucha D, Azeem K, Kollarova H Abstract INTRODUCTION: Adiponectin is a peptide secreted by adipocytes, whose reduction is connected with obesity-related diseases, including insulin resistance. The study analyzed levels of total adiponectin and its high molecular weight (HMW) oligomer in a group of metabolically healthy adults and in patients with type 2 diabetes mellitus (T2DM) to evaluate these levels as potential predictors of the development of insulin resistance. Material and mehods: The study comprised 269 metabolically healthy adults and 300 patients with T2DM. Anthropometric and biochemical indices were measured, including total and HMW adiponectin levels, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index was calculated, logistic regression analysis with continuous predictors for insulin resistance prediction was used. RESULTS: In healthy individuals, both total and HMW adiponectin levels were significantly higher than in diabetic patients. Total and HMW adiponectin levels were adequately correlated with the HOMA-IR. Logistic regression analysis showed that increased levels of both total adiponectin (odds ratio [OR] 0.598, 95% confidence interval [CI] 0.483-0.723) and the HMW form (OR 0.360, 95% CI 0.242-0.511) are a protective factor for ...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research