Successful live birth in a patient who underwent cranial radiotherapy and systemic chemotherapy by implantation of a cryopreserved blastocyst on day 7.

Successful live birth in a patient who underwent cranial radiotherapy and systemic chemotherapy by implantation of a cryopreserved blastocyst on day 7. Clin Exp Obstet Gynecol. 2017;44(3):467-469 Authors: Hayashi C, Chishima F, Matsumoto K, Kato E, Shinya K, Nakao T, Nakamura A, Yamamoto T Abstract Preservation of fertility has been recommended for cancer-bearing patients of reproductive age before undergoing cancer treatment. However, there are many considerations and it is difficult to preserve fertility for all patients undergoing therapy for malignancies. Female cancer survivors had lower pregnancy and live birth rates compared with others that underwent assisted reproductive technologies (ARTs). We should continue to consider the issue of infertility in patients who underwent therapies for malignancies. This is the first report of a successful live birth in a patient with a cranial tumor who underwent radiotherapy and chemotherapy after implantation of an autologous embryo. The patient was a 27-year-old Japanese woman. She was diagnosed with suprasellar germinoma at 13 years of age, and she developed panhypopituitarism after radiotherapy and chemotherapy. At 27 years of age, she began infertility treatment with in-vitro fertilization (IVF). The level of anti-Mallerian hormone (AMH) was 4.29 ng/ml. After ovarian stimulation by high purified human menopausal gonadotropin (HP-hMG), she obtained two blastocysts and became pregnant by implantation of a cr...
Source: Clinical and Experimental Obstetrics and Gynecology - Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research

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This study evaluated the association between BRCA mutation status and serum anti-Müllerian hormone (AMH) level in young, reproductive-aged patients with breast cancer. Materials and Methods: Patients ≤ 40 years of age with breast cancer and who had known BRCA status and baseline serum AMH level at Samsung Medical Center, Seoul, Korea, were considered for inclusion. A total of 52 BRCA mutation carriers (27 BRCA1 and 25 BRCA2) and 264 non-carriers were selected for analyses. The serum level of AMH was compared according to presence of a BRCA mutation, and linear and logistic regression analyses were performed to eva...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Cancer treatment — and cancer itself — can threaten fertility. This is a tremendously important survivorship issue for many people. As an oncologist, I’m often asked questions about preserving fertility during cancer treatment. If this issue affects you, here is an overview of key options. When should you talk to your cancer team about fertility? Future children may not be foremost on your mind when you are diagnosed with cancer. Soon afterward, though, it’s worth talking to your doctor about fertility issues, if this is important to you now or might one day become important. Your doctor can explain...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Fertility Infertility Source Type: blogs
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized fertility Research Source Type: news
CONCLUSION: Our results show that Epstein-Barr infection is possibly associated with autoimmune ovarian failure. The devastating impact on fertility in such disorder can be successfully avoided by in vitro maturation of oocytes from excised ovarian tissue. PMID: 29618356 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Conclusions Except for the risk of premature ovarian failure, a rare adverse effect of combined treatments, both single-agent and multiagent chemotherapy can be safely administered to patients with a desire for childbearing. High-risk patients have worse reproductive outcomes because they undergo hysterectomy more frequently than low-risk patients.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Gestational Cancer Source Type: research
By Katrina Mark, MD 1. Fertility naturally declines as we age That alone doesn’t mean you should start to worry. The general advice I give a woman is if she has been trying to become pregnant for a full year with no luck, she might consider a fertility evaluation. For a woman over age 35, she might consider it after six months. If a woman is younger and has irregular periods, it’s likely she isn’t regularly ovulating, so she might want to be evaluated sooner. 2. Sometimes there’s a reason for infertility – and sometimes, there’s not There are some things we know cause infertility. About...
Source: Life in a Medical Center - Category: Universities & Medical Training Authors: Tags: Health Tips Women's Health fertility Katrina Mark obgyn UMMC Source Type: blogs
This is a guest post from a very thoughtful patient of ours.It describes very eloquently the worries and fears which prey on an infertile patient's mind. It's very hard to discuss them with anyone, and bottling them up just makes things worse !--------------------------------------------------------------------------------------------------------------------------Isn't it a paradox that when India and world's population is exploding at alarming rate; here I am ,struggling to have a single child for 5 long years and with no idea when the struggle will really end.I am being treated at Malpani's and yesterday the doctor urged...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Women who smoke and those who have been exposed to second hand smoke have more problems getting pregnant and are more likely to reachmenopause at an earlier age than women who never smoked or those who were exposed to the least amount of second hand smoke. A new investigation from Roswell Park Cancer Institute reached these conclusions after researchers analyzed data on nearly 89,000 women in the U.S. Women who reported smoking were 14 percent more likely to have infertility (meaning that they were unable to get pregnant for a year) and 26 percent more likely to reach menopause earlier than women who didn’t smoke. Th...
Source: Dr. Weil's Daily Health Tips - Category: Consumer Health News Authors: Tags: Science and Supplement News fertility menopause women's health Source Type: blogs
Conclusion: According to these results, it may be concluded that low AMH levels due to RAI treatment can cause damage to the ovaries of patients; nevertheless, considering the AMH levels and the absence of infertility in the patients, the infertility risk was found to be low. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
ConclusionsBRCAm women should not delay pregnancy, especially if they are BRCA1, older than 35  years or with previous gonadotoxic treatments. Future prospective studies on infertility outcomes in this population are needed.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
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