Lessons Learnt from Epidemiological Investigation of Lassa Fever Outbreak in a Southwest State of Nigeria December 2015 to April 2016

Introduction Lassa fever (LF) is a severe acute viral hemorrhagic illness caused by a virus belonging to the family Arenaviridae.1,2 The disease was first discovered in Sierra Leone in the 1950s, but the aetiological agent was first isolated after an outbreak of the disease in a village called Lassa in Borno State, Nigeria claiming the lives of two foreign missionary nurses in 1969.3 The virus exhibits persistent, asymptomatic infection, with profuse urinary virus excretion in Mastomys natalensis rodents, which serve as the natural reservoir.1,2 The virus is shed in their excreta (urine and faeces) of the rodent which can be aerosolized and inhaled by humans.4 Primary mode of spread is from rodent to man through contact with rodent excreta or urine in food or during hunting and processing of rats for consumption. The virus can spread from person-to-person, either within households during care for sick relatives or in health care settings.5 The disease, LF, is endemic in West Africa with several outbreaks recorded over the years. Outbreaks of the disease have been in reported in Sierra Leone, Guinea, Liberia, Nigeria, Ghana, and Ivory Coast, Senegal and Mali.6 The number of infections per annum has been estimated at 100,000 to 300,000 with approximately 5,000 deaths.6,7,8,9,10 Since the identification of the virus in Nigeria in 1969, yearly outbreaks have been reported in parts of the country,11,12 and more recently in some states including Ondo States.13,14,15,16 Despite t...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

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Source: Hand Surgery - Category: Surgery Authors: Tags: Plast Reconstr Surg Source Type: research
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Source: Hand Surgery - Category: Surgery Authors: Tags: Plast Reconstr Surg Source Type: research
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Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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Source: European Journal of Radiology Open - Category: Radiology Source Type: research
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