The novel function of self-renewal factor of spermatogonial stem cells is identified

(Shinshu University) A research team found a novel function of FGF2 in mammalian testis. Although it has demonstrated that both GDNF and FGF2 are the self-renewal factor for spermatogonial stem cells (SSCs) in vitro, present study revealed that FGF2 acts to facilitate the differentiation of SSCs in vivo. The understanding of molecular mechanism regulating SSCs has potential for future applications for male infertility treatment.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): G.D. Sagaradze, N.A. Basalova, V.I. Kirpatovsky, D.A. Ohobotov, O.A. Grigorieva, V.Yu. Balabanyan, A.A. Kamalov, A.Yu. EfimenkoAbstractMale infertility represents a severe social and medical challenge. In recent years the progress in regenerative medicine promoted the development of novel options to overcome this medical condition. We are elaborating a promising approach to restore spermatogenesis using mesenchymal stromal cell (MSC) secretome components as a novel class of cell-free cell therapy medicinal products for regenerative...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: 6 November 2018Source: Cell Reports, Volume 25, Issue 6Author(s): Brian P. Hermann, Keren Cheng, Anukriti Singh, Lorena Roa-De La Cruz, Kazadi N. Mutoji, I-Chung Chen, Heidi Gildersleeve, Jake D. Lehle, Max Mayo, Birgit Westernströer, Nathan C. Law, Melissa J. Oatley, Ellen K. Velte, Bryan A. Niedenberger, Danielle Fritze, Sherman Silber, Christopher B. Geyer, Jon M. Oatley, John R. McCarreySummarySpermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene expression have been...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: Available online 3 November 2018Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Marc Kanbar, Francesca di Michele, Christine WynsAbstractTransplantation of own cryostored spermatogonial stem cells (SSCs) is a promising technique for fertility restoration when the SSC pool has been depleted.In this regard, cryopreservation of pre-pubertal testicular tissue or SSCs suspensions before gonadotoxic therapies is ethically accepted and increasingly proposed.SSC transplantation has also been considered to treat other causes of infertility relying on the possibility of propagat...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 1 November 2018Source: Stem Cell ReportsAuthor(s): Kaoru Miyazaki, Matthew T. Dyson, John S. Coon V, Yuichi Furukawa, Bahar D. Yilmaz, Tetsuo Maruyama, Serdar E. BulunSummaryDefective endometrial stromal fibroblasts (EMSFs) contribute to uterine factor infertility, endometriosis, and endometrial cancer. Induced pluripotent stem cells (iPSCs) derived from skin or bone marrow biopsies provide a patient-specific source that can be differentiated to various cells types. Replacement of abnormal EMSFs is a potential novel therapeutic approach for endometrial disease; however, the methodology or...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Young boys are often left infertile after childhood cancer treatment, with no way of preserving their sperm. Now, new research might allow them to father children.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Researchers have figured out how to grow human stem cells to help children treated for cancer who become infertile later in life.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Cryptorchidism as a common genitourinary malformation with the serious complication of male infertility draws widespread attention. With several reported miRNAs playing critical roles in spermatogonial stem ce...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
CONCLUSIONS: The miR-34c/Nanos2 pathway provides new insight into the mechanism of male infertility caused by cryptorchidism. Our results indicate that miR-34c may serve as a biological marker for treatment of infertility caused by cryptorchidism. PMID: 30322389 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Publication date: Available online 10 October 2018Source: Trends in GeneticsAuthor(s): Aaron C. Goldstrohm, Traci M. Tanaka Hall, Katherine M. McKenneyMammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory networks, biological functions, and relevance to diseases. Pumilio proteins bind an extensive network of mRNAs and repress protein expression by inhibiting translation and promoting mRNA decay. Opposingly, in certain contexts, they can activate protein expression. Pumilio proteins also regulate noncoding (...
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research
Abstract Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory networks, biological functions, and relevance to diseases. Pumilio proteins bind an extensive network of mRNAs and repress protein expression by inhibiting translation and promoting mRNA decay. Opposingly, in certain contexts, they can activate protein expression. Pumilio proteins also regulate noncoding (nc)RNAs. The ncRNA, ncRNA activated by DNA damage (NORAD), can in turn modulate Pumilio activity. Genetic analysis provides new insig...
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Tags: Trends Genet Source Type: research
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