A Natural Occurring Mouse Model with < b > < i > Adgrv1 < /i > < /b > Mutation of Usher Syndrome 2C and Characterization of its Recombinant Inbred Strains

Conclusion: We isolated a mouse strain with hearing loss from inbred mice with retinal degeneration and established it as a recombinant inbred strain with a spontaneous mutation inAdgrv1, the human Usher syndrome 2C gene. The retinal degeneration was cause by a mutation inPde6b, while the hearing loss was caused by a mutation inAdgrv1.Cell Physiol Biochem 2018;47:1883 –1897
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research