Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1+/- mice.

CONCLUSIONS: The differential sensitivity of basal synaptic transmission and LTP to MEK inhibition indicates that the effects of SYNGAP1 deficiency on these synaptic parameters are mediated by distinct pathways. Our findings also suggest that at least some physiological phenotypes of the germline Syngap1 mutation can be ameliorated by pharmacological treatment of adult animals. PMID: 29940508 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29940508?dopt=Abstract

Source: Pharmacological Reports - June 22, 2018 Category: Drugs & Pharmacology Authors: Kopanitsa MV, Gou G, Afinowi NO, Bayés À, Grant SGN, Komiyama NH Tags: Pharmacol Rep Source Type: research