Combination of LABA + Inhaled Glucocorticoid Safe in Asthma

Also results in significantly fewer asthma exacerbations than inhaled glucocorticoid alone
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Internal Medicine, Allergy, Pediatrics, Pharmacy, Pulmonology, Journal, Source Type: news

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Publication date: Available online 19 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Juan Carlos Cardet, Christopher D. Codispoti, Tonya S. King, Leonard Bacharier, Tara Carr, Mario Castro, Vernon Chinchilli, Ryan Dunn, Fernando Holquin, Linda Engle, Kyle Nelson, Victor E. Ortega, Michael Peters, Sima Ramratnam, Jerry A. Krishnan, Michael E. Wechsler, Elliot Israel, NHLBI Asthmanet
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractPurpose of review:Children with allergic rhinitis (AR) have a high risk of developing asthma. An effect beyond end of allergen immunotherapy (AIT) has been demonstrated, and moreover a preventive effect on the development of asthma in children with AR is suggested. The aim of this review is to discuss the evidence for the asthma preventive capacity of AIT.Recent findings:According to the recently published systematic review and clinical practice AIT guideline from The European Academy of Allergy and Clinical Immunology (EAACI), there is sufficient evidence to recommend a 3-year course of AIT for children and adoles...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
To review the history of the penicillin minor determinants and evaluate their relevance for current diagnosis.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
Eosinophils are associated with allergic asthma and GM-CSF intrinsically promotes their accumulation in the inflamed lung
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Measurement of urinary leukotriene E4 (uLTE4) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene (CysLT) production and changes in CysLT production. Recent studies have reported on novel LTE4 receptor interactions and genetic polymorphisms causing CysLT variability. The applications of uLTE4 as a biomarker continue to expand, including evaluation of environmental exposures, asthma severity risk, aspirin sensitivity, predicting atopy in preschool age children, obstructive sleep apnea, and predicting susceptibility to leukotriene receptor antagonists.
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
Diagnosis and management of asthma is commonly implemented based on clinical assessment. Although these nonmolecular biomarkers have been useful, limited resolution of the heterogeneity among asthmatic patients and little information regarding the underlying pathobiology of disease in individuals have been provided. Molecular endotying using global transcriptome expression profiling associated with clinical features of asthma has improved our understanding of disease mechanisms, risk assessment of asthma exacerbations, and treatment responses, especially in patients with type 2 inflammation. Further advances in establishin...
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
Chronic rhinosinusitis is a complex disease that exists along the inflammatory spectrum between types 1 and 2 inflammation. The classic phenotypic differentiation of chronic rhinosinusitis based on the presence or absence of inflammatory polyps remains one of the best differentiators of response to therapy. Development of biologics for the treatment of atopic disease and asthma and topical therapies for sinusitis have placed renewed emphasis on understanding the pathophysiology of polyp disease. Identification of key markers of polyposis will allow for better stratification of inflammatory polyp disease endotypes to object...
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
Vernal keratoconjunctivitis (VKC) is a bilateral inflammatory ocular condition often brought on by an allergic response. Patients with VKC commonly exhibit ocular symptoms such as photophobia, redness of the eyes, itching, discharge, and lacrimation, which can have profound effects on quality of life. The pathogenesis of the disease is both immunoglobulin E (IgE) and non-IgE mediated, invoking several hypersensitivity mechanisms. The treatment for VKC is mainly centered on symptom control with the use of antihistamines, calcineurin inhibitors, and corticosteroids.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Eosinophils are critical in asthma biology, contributing to symptoms, airflow obstruction, airway hyperresponsiveness, and remodeling. In severe asthma, in addition to local maturation in bone marrow, in situ eosinophilopoiesis plays a key role in the persistence of airway eosinophilia. Local milieu of structural, epithelial and inflammatory cells contribute by generating eosinophilopoietic cytokines in response to epithelial-derived alarmins. Another mechanism of persistent airway eosinophilia is glucocorticosteroid insensitivity, which is linked to recurrent airway infections and presence of local autoantibodies. Novel m...
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
It is vital for any field in medicine to attract the best and brightest learners to ensure that the specialty continues to provide outstanding clinical care and cutting-edge research. This is especially true for the field of Allergy and Immunology (AI) as graduates of AI training programs have a very large depth and breadth of environments in which to practice, from private practice to faculty at a large tertiary care medical center to working in industry, integrated healthcare organizations, or for the government.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
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