Combination of LABA + Inhaled Glucocorticoid Safe in Asthma
Also results in significantly fewer asthma exacerbations than inhaled glucocorticoid alone
CONCLUSION: For controlling rhinoconjunctivitis symptoms in patients with AR, AH-LTRA provided greater beneficial effects on composite nasal symptoms, rhinorrhea, and sneezing compared to AH alone. These effects were shown in patients with perennial AR. PMID: 31007040 [PubMed - as supplied by publisher]
We appreciated the article by Cardet and Casale,1 who focused on the current status of omalizumab treatment in its authorized applications (ie, severe allergic asthma not controlled by standard therapy and chronic spontaneous urticaria not controlled by antihistamines), as well as off-label use in a number of other IgE-mediated or non –IgE-mediated diseases.
Allergic rhinoconjunctivitis (ARC) is a very common chronic inflammatory disease of the upper airways, characterized by symptoms such as nasal congestion, rhinorrhea, sneezing, itching and also itchy-watery eyes 1. The disease has an estimated worldwide prevalence of 15-25% 2 carrying a high global burden particularly among children and adolescents 2,3.
Eosinophilic esophagitis (EoE) is a chronic, allergy/immune-mediated disease diagnosed in patients with symptoms of esophageal dysfunction, an esophageal eosinophilic infiltrate, and without potential competing causes of eosinophilia.1 While EoE is classified as a rare disease with
Penicillin allergy is the most commonly reported drug allergy. While 10% of patients report a penicillin allergy, up to 15% of hospitalized patients report a penicillin allergy.1-3 Given that 90-95% of patients with a reported penicillin allergy tolerate penicillin,4 hospitalized patients with infections often unnecessarily avoid penicillins and other beta-lactams, such as the cephalosporins. Reporting a history of penicillin allergy can result in the choice of a clinically-inferior antibiotic5,6 and lead to more adverse effects.
Conclusion: These results contrast with previous reports of exacerbated AAD in SCD mice exposed to OVA and support the alternative hypothesis that asthmatic responses are normal in those with SCD.Int Arch Allergy Immunol
Conclusions: In asthma and allergy, multimorbidity and polypharmacy are major concerns. Disease severity, drug use, and costs increased with multimorbid conditions. To reduce the burden, allergy management should be better integrated and more comprehensive.Int Arch Allergy Immunol
Little is known about the association of urticarial vasculitis (UV) with thyroid autoimmunity. The latter has been mostly described in the setting of patients with chronic spontaneous urticaria (CSU). In this ...
In this study, we investigated the protective effects of geniposide on dexamethasone (DEX)-induced osteogenic inhibition in MC3T3-E1 cells. The results showed that there was no obvious toxicity on MC3T3-E1 cells when geniposide was used at the doses ranging from 1 to 75 μM. In DEX-treated MC3T3-E1 cells, geniposide promoted the alkaline phosphatase (ALP) activity and the mineralization. In addition, geniposide also significantly increased the mRNA and protein expression of osteopontin (OPN), Runt-related transcription factor 2 (Runx2), and Osterix (Osx) in DEX-treated MC3T3-E1 cells. Furthermore, geniposide activated ER...
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influenza...