Cognitive abilities poorer in older patients with diabetes
Ageing patients with type-1 or type-2 diabetes have a more significant cognitive decline, according to a study inDiabetes Care.Healio
Differences in response to treatment and other characteristics help determine which of your type 2 patients actually have type 1 diabetes.Medscape Internal Medicine
ObjectiveThe meta ‐analysis was aimed to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (PTPN22 rs2476601C/T, INS rs689A/T andTCF7L2 rs7903146C/T) with Latent Autoimmune Diabetes in Adults (LADA).MethodA systematic search of electronic databases was carried out to pool data from 16 independent case ‐control studies for three gene variants until 2017. The pooled allele and genotype frequencies for each T1D and T2D gene variants were used to calculate odds ratio with 95% confidence interval to assess the strength of the association. Heterogeneity test and evaluation of p...
ConclusionA standardized DKA order set was as effective and safe in type 1 and type 2 diabetes as individual physician management in an academic care setting. Further study is needed to assess its value in community hospital settings with less expertise and diabetes specialty services.
ConclusionsOverall, two thirds of the pediatric T2DM guidelines were moderate to low quality and the remaining third ranked higher in quality. Low quality was especially due to the scores for the “Rigour of Development” domain, which directly measures guideline development methodology. It is important that future guidelines and updates of existing guidelines improve the methodology of development and quality of reporting in order to appropriately guide physicians managing children and ad olescents with T2DM.Systematic review registrationPROSPEROCRD42016034187
This article reviews recent studies in both diabetic patients and in these animal models, and discusses novel hypotheses to delineate the increased incidence of heart failure in diabetic patients.
ConclusionsThis is the first comprehensive study of MODY variants in an unselected population ‐based pediatric diabetes cohort. The observed prevalence, increasing access to rapid and affordable genetic screening, and significant clinical implications suggest that genetic screening for MODY could be considered for all children with diabetes, irrespective of other clinical features.
During Diabetes Awareness Month, we look at the differences in the disease.
Diabetes mellitus is common and complicates 2 –5% of pregnancies in the UK, with an increasing prevalence of pre-existing diabetes mellitus in pregnancy. Hyperglycaemia directly correlates with adverse maternal and fetal outcomes, including congenital anomaly, miscarriage, pre-eclampsia, pre-term delivery, macrosomia, stillbirth and neonatal hypoglycaemia. Optimal glycaemic control before conception and during the antenatal period is paramount to reduce these risks. Pre-pregnancy preparation should focus on glycaemic control, medication review and end-organ disease assessment.
Purpose of review Type 2 diabetes and obesity during childhood, puberty, and adulthood have become more common. This trend presents a global problem in terms of public health and health economics. Associations between intrauterine exposure to hyperglycemia, obesity, and abnormal glucose tolerance (AGT) in offspring have been reported in populations at high risk of diabetes such as Pima Indians, but these associations have not been established in other groups. In this review, we summarize the evidence on obesity and AGT in the offspring of mothers with diabetes. Recent findings Although there are many reports indicatin...
ConclusionsThe following variantsTNFRSF11B (rs2073618, rs2073617, rs1872426, rs1032128, rs7464496, rs11573829 and rs1485286),COLEC10 (rs6993813, rs3134069) andTNFSF11 (rs9533156) present differences in allele frequencies in diabetic foot patients and show correlation with gender, diabetes type and diabetic foot etiology.