Two Boston-area biotechs focused on kidney disease, Keryx and Akebia, to merge

Two Boston-area biotech firms that specialize in drugs for chronic kidney disease — Cambridge-based Akebia Therapeutics and Boston-based Keryx Biopharmaceuticals — will merge and form a company worth $1.3 billion. On Thursday morning, the two companies announced that both boards have approved the plan. The combined company will be named Akebia Therapeutics (Nasdaq: AKBA) and will be led by that company’s CEO, John Butler. The two companies would have more than 300 combined employees, barring…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Source Type: news

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Publication date: Available online 14 July 2018Source: American Journal of Kidney DiseasesAuthor(s): Sharon H. Saydah, Hui Xie, Giuseppina Imperatore, Nilka Rios Burrows, Meda E. PavkovRationale &ObjectiveAlbuminuria and low estimated glomerular filtration rate (eGFR) define chronic kidney disease in adults and youth. Different from adults, the burden of abnormal kidney markers among youth in the general United States population is largely unknown.Study DesignSerial cross-sectional national surveys.Setting &ParticipantsAdolescents aged 12 to 18 years participating in the National Health and Nutrition Examination Su...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Authors: Kim HJ, Oh YN, Ju MH, Kim JB, Jung SH, Chung CH, Lee JW, Choo SJ Abstract Background: We reviewed our experience with on-pump beating (OPB) heart coronary artery bypass grafting (CABG) to evaluate the impacts of obviating aortic cross-clamping and cardioplegic arrest on clinical outcomes compared with conventional CABG (C-CABG). Methods: Between 2006 and 2012, elective isolated cardiopulmonary bypass (CPB)-assisted CABG was consecutively performed in 645 patients (mean patient age 63.3±9.1 years, 471 women) with 254 (39.4%) undergoing OPB-CABG and 391 (60.6%) undergoing C-CABG. The early and lon...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
The Journal of Clinical Hypertension, EarlyView.
Source: The Journal of Clinical Hypertension - Category: Cardiology Authors: Source Type: research
Authors: Ono Y, Takamatsu H, Inoue M, Mabuchi Y, Ueda T, Suzuki T, Kurabayashi M Abstract The effectiveness of long-term administration of tolvaptan in heart failure (HF) patients with chronic kidney disease (CKD) has not been fully studied. Hence, in this study, we investigated the effects of chronic administration of tolvaptan on patients with HF and CKD. We consecutively enrolled 31 patients with acute HF syndrome (AHFS) who were administrated tolvaptan as a long-term medication (TLV group). All patients had a history of prior HF admission and CKD. We also consecutively enrolled 27 patients with AHFS, a prior hi...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Authors: Vallianou NG, Mitesh S, Gkogkou A, Geladari E Abstract Chronic Kidney Disease is a growing health burden world widely. Traditional and mutual risk factors between CVD and CKD are age, hypertension, diabetes mellitus, dyslipidemia, tobacco use, family history and male gender. In this review, we will focus on whether or not early CKD is an important risk factor for the presence, severity and progression of CVD. Specifically, we will examine both traditional and novel risk factors of both CKD and CVD and how they relate to each other. We will also assess if early treatment of CKD, intensive compared to standa...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have r...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
In this study, we investigated the diagnostic value of human epididymis protein 4 (HE4) in acute and chronic renal dysfunction and analyzed the correlation between HE4 levels and the results of routine renal function tests. We aimed to provide evidence to establish HE4 as a novel biomarker of renal injury and its appropriate application as a marker of ovarian cancer.MethodsWe collected 259 serum samples from hospitalized patients with different causes of renal damage. HE4 serum levels were detected by chemiluminescence and the levels of serum creatinine, urea, and cystatin C were tested by conventional clinical chemical me...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Kidney fibrosis is a histological hallmark of chronic kidney disease and arises in large part through extracellular matrix deposition by activated fibroblasts. The signaling protein complex mTOR complex 2 (mTORC2) plays a critical role in fibroblast activation and kidney fibrosis. Protein kinase Cα (PKCα) is one of the major sub-pathways of mTORC2, but its role in fibroblast activation and kidney fibrosis remains to be determined. Here, we found that transforming growth factor β1 (TGFβ1) activates PKCα signaling in cultured NRK-49F cells in a time-dependent manner. Blocking PKCα signaling ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Signal Transduction Source Type: research
"Why I Chose Hemodialysis Over Peritoneal Dialysis": An Opinion Survey Among In-Center Hemodialysis Patients. Perit Dial Int. 2018 Jul-Aug;38(4):305-308 Authors: Valson AT, Asad RA, Radhakrishnan RC, Sinha S, Jacob S, Varughese S, Tamilarasi V Abstract Peritoneal dialysis (PD) penetration in India remains low despite the huge chronic kidney disease burden and unmet need for renal replacement therapy (RRT). In order to understand the socioeconomic reasons that govern patients' preference for hemodialysis (HD), we carried out an opinion survey among prevalent in-center HD patients at our instit...
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
ConclusionsBoth lower eGFR and higher ACR are independently associated with measures of central arterial stiffness, with stronger associations for ACR over eGFR. Our findings suggest that central arterial stiffness may be an important pathophysiologic phenotype of vascular disease in CKD.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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