Glutamine Metabolism in Cancer.

Glutamine Metabolism in Cancer.
Adv Exp Med Biol. 2018;1063:13-32
Authors: Li T, Le A
Abstract
KEY POINTS: Dysregulation of the TCA cycle and glutamine addiction are characteristic features of glutamine metabolism in cancers. Targeting glutamine metabolism in cancer includes inhibition of glutaminolysis by glutaminase inhibitors, combination therapy, knockdown of c-MYC, inhibition of GDH, depletion of glutamine supply, inhibition of glutamine uptake, and usage of glutamine analogs. Transaminase upregulation and targeting amino acid synthesis have potential for cancer therapy.
PMID: 29946773 [PubMed - in process]

Source: Advances in Experimental Medicine and Biology - June 28, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research