Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model.
In this study, we examined effects of Tat-DJ-1 protein on streptozotocin (STZ)-induced diabetic mice. Wild type (WT) Tat-DJ-1 protein transduced into pancreas where it markedly inhibited pancreatic β-cell destruction and regulated levels of serum parameters including insulin, alkaline phosphatase (ALP), and free fatty acid (FFA) secretion. In addition, transduced WT Tat-DJ-1 protein significantly inhibited the activation of NF-κB and MAPK (ERK and p38) expression as well as expression of COX-2 and iNOS in STZ exposed pancreas. In contrast, treatment with C106A mutant Tat-DJ-1 protein showed no protective effects. Collectively, our results indicate that WT Tat-DJ-1 protein can significantly ameliorate pancreatic tissues in STZ-induced diabetes in mice.
PMID: 29936932 [PubMed - as supplied by publisher]
Source: BMB Reports - Category: Biochemistry Authors: Yeo HJ, Yeo EJ, Shin MJ, Choi YJ, Lee CH, Kwon HY, Kim DW, Eum WS, Choi SY Tags: BMB Rep Source Type: research
More News: Biochemistry | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Endocrinology | Insulin | Pancreas | Study