Better Imaging for Prostate Cancer Patients?

The objective [of LOCATE] was to access the impact of positron imaging for patient management,” Peter Gardiner, Blue Earth Diagnostics CMO, told MD+DI. “These were men with recurrent prostate cancer.” For the LOCATE trial 213 men with biochemically recurrent prostate cancer were evaluated with 18F-fluciclovine PET/CT after having negative or equivocal findings on conventional imaging, such as a bone scan, CT or MRI. This first prospective multi-center study was conducted at 15 sites in the U.S., including both private practices and academic settings. It focused on the association between scan positivity and the clinical variables of recurrence site, practice setting, prostate-specific antigen (PSA) level, and Gleason score (system of grading prostate cancer). Questionnaires completed by treating physicians documented changes in management after the PET study. Trial results showed that 59% (126/213) of patients had their clinical management changed by findings from 18F-fluciclovine imaging. Of those changes, 78% (98/126) were classified as major. Disease was detected in the prostate, as well as other tissue, including pelvic and abdominal lymph nodes and, less commonly, bone. Both positive and negative scans impacted patient management. No difference was seen in the rate of positive scans or in the rate of management changes between private practices and academic settings. In addition, no association was found between Gleason score at diagnosis and positive scans. Plans ...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Testing Source Type: news