Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells

ConclusionsDecreased splicing efficiency and global intron retention is a novel stress response mechanism that may promote survival of malignant cells following therapy. We found that this mechanism can be inhibited by pladienolide B, which significantly increases the sensitivity of cancer cells to cisplatin which makes it a good candidate drug for improving the efficiency of cancer therapy.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research