The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes.

The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes. Int J Dev Biol. 2018;62(6-7-8):453-464 Authors: Singh SP, Ninov N Abstract On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes. PMID: 29938757 [PubMed - in process]
Source: International Journal of Developmental Biology - Category: Biology Tags: Int J Dev Biol Source Type: research