Lynch Syndrome-associated Upper Tract Urothelial Carcinoma

A 63-year-old female with known history of Lynch Syndrome with MSH2 gene deletion presented to the emergency department with left flank and epigastric pain worsening over one week. She had a three-year history of intermittent gross hematuria, with no masses or hydronephrosis on non-contrast abdominal and pelvic CT scan 2.5 years prior. Review of systems was otherwise negative. Patient reported previously negative evaluation with cystoscopy and repeat urinalysis for gross hematuria by outside urologist.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research

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CONCLUSIONS: Local application of sevoflurane in the wound bed appears to exhibit analgesic, antimicrobial, and positive healing effects. It could be a promising alternative treatment to be included as a therapeutic option for wound care. PMID: 31730517 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: This is the largest cohort reported in the literature of patients with frostbite injuries treated with HBOT. Hyperbaric oxygen therapy may show positive impact on the demarcation level of frostbite and, despite the common side effects, it generally causes no long-term sequelae. PMID: 31730511 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
ConclusionComputed tomography examinations are a more reliable method for differential diagnosis of thyroid nodules than ultrasound examinations followed by fine needle aspiration biopsy.Level of EvidenceIII.ResumoIntroduçãoA ultrassonografia é um método rápido para determinar de qual nódulo deve-se coletar uma amostra para biópsia por aspiração com agulha fina. Por outro lado, o exame de tomografia computadorizada não é restringido pela atenuação do eco e distingue entre nódulos benignos e malignos.ObjetivoComparar exames tom...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
ConclusionThe radiomics features extracted from Gd-EOB-DTPA-enhanced MR images can be used to diagnose preoperative DPHCC. DPHCC is more likely to recur and cause death than HCC, suggesting that active postoperative management of patients with DPHCC is required.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionAlthough classically, majority of studies have shown oncogenic roles of nucleoporins as genetic fusion partners in several types of leukemia, emerging evidence suggests that nucleoporins also modulate many cellular signaling pathways that are associated with several major non-hematological malignancies, such as carcinomas of skin, breast, lung, prostate and colon. Hence, nucleoporins are emerging as novel therapeutic targets in human tumors.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 18 November 2019Source: Materials Chemistry and PhysicsAuthor(s): J.N. Lacerda, D.F. Franceschini, E.A. Ponzio, Laura M. Esteves, R.B. Guimarães, Y.T. XingAbstractManganese oxide nanofoam has been prepared by pulsed laser deposition, from a metallic Mn target in a 5 Torr pressure O2 buffer atmosphere. The as-prepared samples were heat-treated at different temperatures (300 °C - 500 °C) in air. Both as-deposited and heat-treated samples have a high porosity foam-like morphology, as shown by Field Emission Scanning Electron Microscopy. High Resolution Transmission Electron Mi...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Mengya Sun, Jie Ma, Manman Zhang, Yao Xiao, Yuanzheng Zhu, Shuping ZhangAbstractHerein, a novel thiourea modified Fe3O4/graphene oxide magnetic nanocomposite (TMGO) is first constructed for absorbing a dye named Coomassie brilliant blue (CBB) from aqueous solutions. The as-prepared adsorbent is characterized by an X-ray powder diffractometer (XRD), A Fourier transform infrared spectrometer (FTIR), a vibrating sample magnetometer (VMS), a field emission scanning electron microscopy (SEM), a scan transmission electron microscopy (S...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: Available online 17 November 2019Source: Journal of Materials Science &TechnologyAuthor(s): Lin Lu, Qianqian LiuAbstractThis work aimed to study the comprehensive effects of photo-oxidation and biodegradation on different failure stages of polyester coatings, which were exposed to the tropical rainforest atmosphere. The surface morphology, aging products, local aging characteristics and electrochemical behavior of the coatings were characterized with scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR), electrochemical impedance spectroscopy (EIS) and high-resolution disp...
Source: Journal of Materials Science and Technology - Category: Materials Science Source Type: research
In this study, a corrosion-resistant polymer coating with self-cleaning properties on Mg alloy AZ31 was successfully fabricated via a pretreatment of amino-silane (poly(3-aminopropyl)trimethoxysilane, PAPTMS) and subsequently covered with a polypropylene (PP) film. Surface morphology and chemical compositions were examined using field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and Fourier transform infrared spectrophotometry (FT-IR) and X-ray photoelectron spectroscopy (XPS) as well. Contact angle was measured to determine hydrophobicity of the composite coatings. Water permeability of the coa...
Source: Journal of Materials Science and Technology - Category: Materials Science Source Type: research
Publication date: Available online 17 November 2019Source: Journal of Materials Science &TechnologyAuthor(s): Edson Cezar Grzebielucka, João Frederico Haas Leandro Monteiro, Eder Carlos Ferreira de Souza, Christiane Philippini Ferreira Borges, André Vitor Chaves de Andrade, Eloísa Cordoncillo, Héctor Beltrán-Mir, Sandra Regina Masetto AntunesAbstractThe effect of chromium addition on the structure and electrical properties of CaCu3Ti4O12 is studied. Compositions based on the formula CaCu3Ti4-xCrxO12-δ (x = 0, 0.025, 0.050 and 0.075 mol%) are prepared by soli...
Source: Journal of Materials Science and Technology - Category: Materials Science Source Type: research
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