Lyme Disease ‐Associated IgG4 Autoantibodies Correlate with Synovial Pathology in Antibiotic‐Refractory Lyme Arthritis

Arthritis&Rheumatology,Volume 0, Issue ja, -Not available-.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Source Type: research

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(Natural News) Lyme disease is one of the most common vector-borne diseases in the US. The CDC reports that around 30,000 Americans get infected by Lyme every year. However, other data gathering methods suggest that this number can rise to 300,000 cases each year. Because of the rising number of Lyme disease cases, scientists have...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
AbstractPurpose of ReviewSince recognition in 1975, Lyme disease has become the most common vector-borne illness in North America and Europe. The clinical features are well-characterized and treatment is usually curative, but misperceptions about morbidity persist. The purpose of this review is to examine advances in the diagnosis and treatment of Lyme disease, as well as ongoing management challenges.Recent FindingsIt is useful to recognize that Lyme disease occurs in stages, with early- and late-stage disease. Clinical expression is in part determined by Borrelial variability. For example, some strains ofBorrelia burgdor...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
NEW YORK (Reuters Health)—In Lyme disease-endemic areas, a C6 peptide enzyme immunoassay (EIA) test may help guide initial management of children with acute arthritis, an observational study suggests.1 “Children with Lyme disease frequently present to the emergency department with an inflamed joint,” Lise Nigrovic, MD, MPH, of Boston Children’s Hospital tells Reuters Health by email.... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions assay C6 peptide enzyme immunoassay (EIA) Lyme arthritis Lyme Disease Source Type: research
In Lyme disease-endemic areas, a C6 peptide enzyme immunoassay (EIA) test may help guide initial management of children with acute arthritis, an observational study suggests.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Pediatrics News Source Type: news
Conclusions: A significant increase (P = .02) in Lyme arthritis cases was observed at Oishei Children's Hospital of Buffalo. Lyme arthritis may clinically present similarly to other forms of arthritis, such as oligoarticular juvenile idiopathic arthritis, so health care providers should be aware of distinguishing clinical features, which include rapid onset of swelling and patient age. Because the geographic area of endemic Lyme disease is expanding, all health care providers need to be aware of Lyme arthritis as a possible diagnosis. PMID: 31819695 [PubMed]
Source: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders - Category: Orthopaedics Tags: Clin Med Insights Arthritis Musculoskelet Disord Source Type: research
ConclusionThis study of the clinical spectrum of LD in Canadian children underlines the need for preventive measures to protect children in Canada from emerging LD, and the need for health care provider awareness.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Single multiplexed assays could replace the standard 2-tiered (STT) algorithm recommended for the laboratory diagnosis of Lyme disease if they perform with a specificity and a sensitivity superior or equal to those of the STT algorithm. We used human serum rigorously characterized to be sera from patients with acute- and convalescent-phase early Lyme disease, Lyme arthritis, and posttreatment Lyme disease syndrome, as well as the necessary controls (n = 241 samples), to select the best of 12 Borrelia burgdorferi proteins to improve our microfluidic assay (mChip-Ld). We then evaluated its serodiagnostic performance in compa...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research
(Natural News) After going outside, it may be best to do a tick check. Lyme disease is a dangerous condition that causes fever, rashes, face paralysis, and arthritis. Without proper care, it can even lead to death. Interestingly, something so deadly comes from the bite of something so small: ticks. Ticks are tiny arachnids commonly found...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
(Natural News) Lyme disease and rheumatoid arthritis are two different diseases that share many symptoms. A patient will benefit from knowing how to tell them apart. The diseases have different origins. Lyme disease is a bacterial disease caused by the bacteria Borrelia burgdorferi, which infect humans via tick bites. Meanwhile, rheumatoid arthritis stems from a mixture of...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Abstract16 ‐year‐old boy with severe obesity presented to the pediatric rheumatology clinic with a 1.5‐year history of right knee swelling. Laboratory findings were unremarkable other than mildly elevated inflammatory markers. Lyme screen was negative. A previous knee MRI reported a large joint effusion with synovitis and few punctate foci of low signal intensity throughout the synovium, concerning for pigmented villondodular synovitis.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Clinical Image Source Type: research
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