Inhibitory receptor expression on T cells as marker of disease activity and target to regulate effector cellular responses in Rheumatoid Arthritis

Arthritis&Rheumatology,Volume 0, Issue ja, -Not available-.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Source Type: research

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Publication date: Available online 12 September 2019Source: Joint Bone SpineAuthor(s): Thomas El Jammal, Mathieu Gerfaud-Valentin, Pascal Sève, Yvan JamillouxAbstractThree Janus kinase (JAK) inhibitors, ruxolitinib, tofacitinib, and baricitinib, are currently approved by the FDA/EMA for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative rectocolitis. The inhibition of JAK/STAT signaling by these small molecules, downstream of several cytokine receptors, results in lower pro-inflammatory gene expression. Given the cytokine profiles observed in rheumatologic diseases, most of the recent therape...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
AbstractPurposeTo determine if a novel individualized-ultrasound (IUS) method can detect more joints with erosion(s) in rheumatoid arthritis (RA) patients versus existing methods.Materials and methodsThe IUS method selects up to 7 or 14 ultrasonographically most inflamed joints whereas existing methods pre-fix 7 or 14 joints for ultrasonography. Using ultrasonography, the mean total inflammatory score (TIS), mean number of affected joints and mean number of joints with erosion(s) were compared between novel and existing methods among 30 RA patients using the paired Studentt test.ResultsUsing 7-joint approach, comparing IUS...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
ConclusionsAnti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS.Key Points• One-year anti-TNF therapy halted generalized bone loss in association with clinical improvement in arthritides.• Anti-TNF therapy may inversely act on DKK-1 and SOST.• Independent predictors of BMD were SOST and βCTX in RA, while CRP in AS.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsA clinical-genetic model including BMI and SNP FPGS 10101 was found to have a modest prediction ability for methotrexate intolerance.Key Points•Methotrexate intolerance (symptomatic adverse effects) was common and occurred in 37% patients over 6  months.•SNP FPGS rs10106 and low body mass index were associated with methotrexate intolerance.•Clinico-genetic model had a modest ability of 66% for predicting intolerance.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
We present two identical twin sarcoidosis patients with carpal tunnel syndrome. A number of factors may cause carpal tunnel syndrome like wrist anatomy, occupation, diabetes, rheumatoid arthritis, pregnancy and renal failure. Although the above factors do not directly cause carpal tunnel syndrome, they may increase your chances of developing or aggravate median nerve damage as it is in sarcoidosis. Sarcoidosis relevant neuropathy and granulomas may be the primary mechanism of sarcoidosis associated carpal tunnel syndrome. Although rare, carpal tunnel syndrome may be a feature of sarcoidosis that may lead to irreversib...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
In this study we assessed the incidence and the predictors of new-onset LVDD in RA patients. Two-hundred-ninety-five adults with RA without overt cardiac disease were prospectively analyzed from March 2014 to March 2015 by Doppler echocardiography. Among the 295 subjects evaluated, 217 (73.6%) had normal LV diastolic function and represented the final study population. At 1-year follow-up, 53 of 217 patients (24%) developed LVDD, which was of degree I (mild dysfunction) in all of them. By multivariate logistic regression analysis, lower E/A ratio of transmitral flow (ratio between the peak velocity of early diastolic "...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Authors: Cavazzana I, Vizzardi E, Franceschini F Abstract A high rate of left ventricular diastolic dysfunction (LVDD) has been described in rheumatoid arthritis (RA), compared with general population. A prospective study demonstrated that LVDD occurred in 24% in one year of follow-up in RA patients without cardiac disease. Older age, higher systolic arterial pressure and lower E/A ratio are considered predictive factors. In addition, in RA, LVDD is known to be the only risk factor for the development of cardiovascular (CV) events, also in absence of classical CV risk factors. Some occasional reports suggest that e...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Publication date: Available online 12 September 2019Source: Reumatología Clínica (English Edition)Author(s): Jesús Loarce-Martos, Sandra Garrote-Corral, Francesca Gioia, Javier Bachiller-CorralAbstractA large number of complications have been associated with rheumatoid arthritis (RA), those of infectious aetiology being of special relevance. Their high incidence is closely linked to the use of immunosuppressive medication.The spectrum of agents causing opportunistic infections in patients with RA is very broad; however, there are relatively few cases of Leishmania infection, especially in patients not ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Detecting interstitial lung disease in RA patients can be challenging. But evaluating risk factors and the use of imaging can help clinicians identify and manage this condition in patients...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis EULAR ILD imaging Interstitial Lung Disease Methotrexate Rheumatoid Arthritis (RA) Risk Factors Source Type: research
Eating vegetables may help soothe the pain caused by rheumatoid arthritis. A plant-based diet can help with weight loss and relieve the inflammation associated with rheumatoid arthritis, according to new research.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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