Clamor for GSK Shingles Shot Points to Bigger Profits Clamor for GSK Shingles Shot Points to Bigger Profits

GlaxoSmithKline is facing"unprecedented" demand for its new shingles vaccine Shingrix, suggesting the product could be a bigger money-spinner than the company and analysts initially thought.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Business of Medicine News Source Type: news

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Shingles is caused by the varicella-zoster virus -- the same virus that causes chickenpox. If you've had chickenpox, the virus can lie dormant in your body's nerve tissue for years when suddenly it's triggered by stress or a weakened immune system, and manifests as shingles. A new shingles vaccine called Shingrix is recommended for anyone [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Zostavax is a live-attenuated varicella zoster virus (VZV) vaccine recommended for use in adults>50 years of age to prevent shingles. The main risk factor for the development of shingles is age, which correlates with decreasing cell-mediated immunity. These data suggest a predominant role of T cell immunity in controlling VZV latency. However, other components of the immune system may also contribute. In this review, we will discuss how the immune system responds to Zostavax, focusing on recent studies examining innate immunity, transcriptomics, metabolomics, cellular, and humoral immunity. PMID: ...
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research
Authors: Klaric JS, Beltran TA, McClenathan BM Abstract Herpes zoster (HZ, shingles) affects individuals (60+ years) by reactivation of varicella virus from primary infection. Approximately one-third of the general population will develop HZ and are at increased risk of stroke. Our objective was describing possible associations between self-reported HZ vaccination and stroke with the Centers for Disease Control and Prevention's Behavioral Risk Factors Surveillance System, a cross-sectional nationwide telephone survey. Non-institutionalized U.S. adults answered items concerning health risk behaviors. 2014 survey dat...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Title: Shingles Vaccine (Zoster Shingles Vaccine Live, Zostavax)Category: MedicationsCreated: 11/9/2010 12:00:00 AMLast Editorial Review: 3/13/2019 12:00:00 AM
Source: MedicineNet Skin General - Category: Dermatology Source Type: news
PMID: 30776802 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
Felicia D. Goodrum Sterling Heidi L. Pottinger By FELICIA D. GOODRUM STERLING, PhD and HEIDI L. POTTINGER, DrPH, MPH, MA The measles outbreak in Washington state this week has brought new attention to the anti-vaccine movement.  In fact, the World Health Organization recently identified “vaccine hesitancy” as one of top threats to global health. In the US, the number of unvaccinated children has quadrupled since 2001, enabling the resurgence of infectious diseases long-since controlled.  In fact, the WHO claims a staggering 1.5 million deaths could be prevented worldwide by improved vaccination rates....
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Patients Felicia Goodrum Sterling Global Health Heidi L. Pottinger public health The OpEd Project vaccines Source Type: blogs
AbstractHerpes zoster (shingles) is the reactivation of dormant varicella zoster virus in individuals who previously experienced varicella infection or vaccination. Herpes zoster can occur in pregnancy, although it is rare. This case report describes the clinical presentation and diagnosis of herpes zoster and reviews current recommendations for treatment. Preventative measures and the role of immunization are discussed in addition to clinical implications for intrapartum, postpartum, and newborn care to guide practitioners in caring for women experiencing or exposed to herpes zoster in pregnancy.
Source: Journal of Midwifery and Women's Health - Category: Midwifery Authors: Tags: Clinical Rounds Source Type: research
Shingles is a viral infection that causes a painful blistery rash. According to the?Centers for Disease Control and Prevention,?almost 1 out of every 3 people in the U.S. will develop?shingles?in their lifetime. And the risk goes up with age.? In this Mayo Clinic Radio Radio Health Minute,?Dr. Pritish Tosh, an infectious diseases specialist at Mayo [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
The higher risk for stroke with herpes zoster was not attenuated by antivirals or Zostavax vaccination in older patients, but that shouldn't slow vaccination rates or further study.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news
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