Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production
Iron accumulation is observed in the brain of patients with neuroinflammatory diseases, yet its functional significance is poorly understood. Wang et al. demonstrate that iron promotes T cell pathogenicity by protecting RNA-binding protein PCBP1 from proteolysis, thereby promoting PCBP1-mediated stabilization of GM-CSF mRNA. These findings indicate that iron homeostasis can be targeted to suppress pathogenic T cells for treatment of neuroinfl ammatory diseases.
Source: Immunity - Category: Allergy & Immunology Authors: Zhizhang Wang, Weijie Yin, Lizhen Zhu, Jia Li, Yikun Yao, Feifei Chen, Mengmeng Sun, Jiayuan Zhang, Nan Shen, Yan Song, Xing Chang Tags: Article Source Type: research