Polio Virus Could Help Treat Brain Cancer. Here ’s How

The idea that viruses may be co-opted to do good rather than harm isn’t entirely new; researchers have been attempting to harness the power of viruses and bacteria for more than a century. Vaccines are the shining example of using bad bugs to do good in priming the immune system to fight disease. But disease-causing viruses aren’t always easy to corral, and attempts to use them to activate the immune system against things other than fellow bacteria and viruses — including cancer, for example — have not been so successful. There is only one approved virus-based treatment for cancer, which uses herpes virus against melanoma. In a new report published in the New England Journal of Medicine, however, scientists led by a team at Duke University report they may have trained another virus to target cancer, by using poliovirus to target brain tumors. Dr. Darell Bigner, emeritus director of the Preston Robert Tisch Brain Tumor Center at Duke University Cancer Center, and his team engineered a poliovirus that was designed to target a difficult-to-treat brain cancer known as glioblastoma. Among a group of 61 people who had failed to respond to current therapies, which include radiation and chemotherapy, 21% who received the poliovirus treatment were alive after three years, compared to 4% who generally survive that long following standard therapy. The virus-based therapy is the culmination of 20 years of work by Bigner’s colleague Dr. Matthias Gromeier, p...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news

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Source: Journal of Neurology - Category: Neurology Source Type: research
hez E Abstract PMID: 31309875 [PubMed - in process]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
ConclusionsComplete perioperative colonoscopy in patients with CRC should be performed to reduce the rate of metachronous carcinoma. Postoperative completion of preoperative insufficiently colonoscoped patients is recommended.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
AbstractPurposeWe conducted this large population-based study to investigate the prognostic significance of N1c.MethodsPatients diagnosed with colorectal cancer from the surveillance, epidemiology, and end results (SEER) database between January 1, 2010, and December 31, 2010, were included in the sample. The primary outcome of interest used in our study was cause-specific survival (CSS). Cox proportional hazards models and Kaplan –Meier methods were used to evaluate the prognostic value of N1c. Propensity score matching (PSM) was implemented to reduce the possibility of selection bias using a logistic regression mod...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
AbstractPurposeMost elderly patients with colorectal cancer have comorbidities and reduced functional reserve, which may increase their risks of postoperative morbidity and mortality, and subsequently influence the treatment choice. Therefore, this study aimed to investigate the treatment choice and compare laparoscopic and open surgery in this setting.MethodsThis retrospective study evaluated 118 patients with colorectal cancer ( ≥ 85 years old between January 2007 and February 2018) to determine the influence of comorbidities on treatment choice, as well as the safety and feasibility of laparoscopic s...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionLateral tongue flap is a simple reliable flap for reconstruction of small- and medium-sized defects following resection of oral cavity cancers in terms of low morbidity and satisfactory functional outcomes. It obviates the need of distant tissue transfer.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
Conclusion Proper oral screening and understanding of the genetic and environmental factors involved in oral carcinogenesis will allow the emphasis of cancer medicine to shift from the therapy of established oral cancer to the prevention of oral carcinogenesis.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
This article mentions key results that lead to a new perspective where cancer stem cells are primarily seen as cells exhibiting increased epigenetic plasticity and increased gene expression variability. This perspective suggests new therapeutical interventions consisting in stabilizing gene expression to control cancer cell proliferation and prevent stochastic gene expression variations that could lead to therapeutic resistance. PMID: 31308849 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
We describe the management of cancer-associated IO near the end of life in a population-based cohort with universal health coverage. METHODS: Patients who died of gastric, colorectal, ovarian, and pancreatic cancers from 2002 to 2015 were identified from the Ontario Cancer Registry. Those with ≥1 hospital admission for IO in the final year of life were identified from administrative data. Management of IO at index admission was categorized as surgery, gastrostomy, stent, feeding jejunostomy, and medical management. Trends in management over the study period were assessed by the Cochran-Armitage test. RESULTS: Th...
Source: Journal of Palliative Care - Category: Palliative Care Tags: J Palliat Care Source Type: research
CONCLUSIONS: Contrary to earlier reports of lower-quality care, patients with and without mental illness had similar preventive and chronic disease management care quality following medical home implementation. PMID: 31310189 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
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