Role of Gut Microbiome in Regulating Reproduction and Its Impact on Fertility Status in Women Living with and Without HIV (R21 Clinical Trial Optional)
Funding Opportunity PA-18-839 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research related to the role of the gut microbiome in regulating metabolism and reproduction, and its impact on the fertility status. The overarching goal is to gain fundamental insight into the possible role of the gut microbiome in regulating reproduction through HPG, HPA, and HPT axes in the brain. The results of the study could lead to development of diagnostic markers (signature microbiomes) for reproductive and metabolic failure. The project is pertinent to multiple portfolios in the Fertility and Infertility Branch, e.g., basic ovarian biology, fertility preservation, assisted reproductive technology, spermatogenesis and sperm function, and therapeutic interventions to infertility. The emphasis on the gut microbiome and its impact on reproduction through its effects on HPG, HPA, and HPT axes leading to obesity, metabolic syndrome, stress disorders, infection and anxiety is also of interest to the Maternal and Pediatric infectious disease Branch, Pediatric Growth and Nutrition Branch and IDDB.
ConclusionsDietary habits of women became less healthy during the transition from pregnancy to 6 years post-pregnancy. However, results should be interpreted with caution due to the different dietary assessment tools used at the two time points.
Millions of Canadian adults are classified as overweight or obese by the Body Mass Index. But according to some experts, the BMI is among many things that should be scrapped as the medical field changes how it looks at obesity.
Dr. Laura Esserman answers the door of her bright yellow Victorian home in San Francisco’s Ashbury neighborhood with a phone at her ear. She’s wrapping up one of several meetings that day with her research team at University of California, San Francisco, where she heads the Carol Franc Buck Breast Care Center. She motions me in and reseats herself at a makeshift home office desk in her living room, sandwiched between a grand piano and set of enormous windows overlooking her front yard’s flower garden. It’s her remote base of operations when she’s not seeing patients or operating at the hospita...
Breast imaging can be associated with substantial anxiety due to the impact of abnormal mammography on distress and perceptions of risk for breast cancer. We sought to determine the level of anxiety after notification of abnormal mammography and need for follow up at a cancer institute and whether or not further distress was provoked by the visit to the ‘cancer institute’ for follow up.
Metabolic syndrome (MetS) has been associated with the development of gallstone disease; however, the impact of MetS on common bile duct (CBD) stones from choledocholithiasis (CDL) and/or gallstone pancreatitis (GSP) after cholecystectomy is unknown.
Due to increased rates of preexisting nutritional deficiencies, decreased baseline functional status, and diminished ability to adapt to metabolic stress, geriatric emergency general surgery (EGS) patients are at high risk for poor outcomes. We sought to evaluate the impact of early vs late initiation of parenteral nutrition (PN) in elderly EGS patients who demonstrated relative short-term contraindications to enteral nutrition.
Obesity has been linked to the development of Colorectal Cancer and to increase morbidity. However, the impact BMI has on surgical staging through nodal harvest is not entirely understood.
Conclusion The periconceptional environment and lifestyle factors modify sperm epigenome. This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. In long term, metabolic disorders have been described in...
Polycystic ovarian syndrome (PCOS), one of the most common endocrine disorders, is associated with diverse health problems including obesity, infertility, metabolic syndrome, uterine cancer, anxiety, and depression. The syndrome is well characterized but the exact etiology is poorly understood. Treatments include lifestyle intervention, medical and surgical therapies, and are tailored to symptoms and treatment goals.
Funding Opportunity PA-18-838 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research related to the role of the gut microbiome in regulating metabolism and reproduction, and its impact on the fertility status. The overarching goal is to gain fundamental insight into the possible role of the gut microbiome in regulating reproduction through HPG, HPA, and HPT axes in the brain. The results of the study could lead to development of diagnostic markers (signature microbiomes) for reproduct...