Flight Attendants Have Higher Rates of Many Cancers, Study Says

Flight attendants are exposed to a number of known cancer-causing risks, but few studies have rigorously quantified that risk, and researchers say they are an understudied occupational group. The Harvard Flight Attendant Health Study (FAHS), begun in 2007, addresses some of the gaps in understanding health risks among flight attendants. In the latest report, published in the journal Environmental Health, researchers found that flight attendants had higher rates of many cancers, including breast cancer and melanoma, compared to the general population. The FAHS included more than 5,300 flight attendants who were recruited through online and mailed surveys, and given in person at airports. The flight attendants answered questions about their flight schedules, as well as any diagnoses of cancer. The researchers, led by Irina Mordukhovich, a research associate at Harvard T. H. Chan School of Public Health, then compared the responses to those from a matched group of people not in the airline profession from an ongoing national health survey. Mordukhovich found higher prevalence of breast, melanoma, uterine, gastrointestinal, thyroid and cervical cancers among the flight attendants compared to the general public. The study also revealed for the first time a higher rate of non-melanoma skin cancers, such as basal cell and squamous cell carcinomas, among flight attendants. The prevalence of breast, melanoma and non-melanoma cancers were especially striking, says Mordukhovich. Fligh...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news

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Source: Life Sciences in Space Research - Category: Biology Source Type: research
In this study, we have shown that NOL8, a binding protein of beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin/TCF signaling. NOL8 is up-regulated in the prostate cancer, and promoted the growth, migration and colony formation of cancer cells. Knocking down the expression of NOL8 inhibited the growth, migration and colony formation of prostate cancer cells. The molecular mechanism study demonstrated that NOL8 promoted the migration and colony formation of cancer cells by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of NOL8 ...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
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Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
In conclusion, the association between allopurinol and teratogenicity appears to be weak and limited to two reports with uncertain causality. However, the available data are insufficient to make a certain judgement, and as allopurinol treatment evolves, report and prospective follow-up of all exposed infants (i.e. deviant and normal cases) should be encouraged.
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Authors: Zhang S, Cai J, Xie W, Luo H, Yang F Abstract MicroRNA (miR)-202 has been reported to be involved in the regulation of human cancer progression including bladder cancer, non-small cell lung cancer, pancreatic cancer and esophageal squamous cell carcinoma. However, the function of miR-202 in prostate cancer remains largely unknown. The present study demonstrated that miR-202 was downregulated in human prostate cancer tissues and cell lines. And overexpression of miR-202 significantly inhibited the proliferation, migration and invasion of prostate cancer cells, but induced cell apoptosis. Moreover, miR-202 s...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Hao B, Chen X, Cao Y Abstract Yes-associated protein 1 (YAP1) is overexpressed in a number of human cancer types as an oncogene and takes part in processes of tumor cell proliferation, apoptosis and metastasis. The Notch pathway also has an important role in tumorigenesis and progression. However, the possible association between YAP1 and Notch signaling in glioma has remained to be determined. The present study verified the high expression of YAP1, Jagged 1 (JAG1), NOTCH1 and HES1 in the U251 glioma cell line via reverse-transcription quantitative polymerase chain reaction and western blot analysis. The e...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Fu M, Li D Abstract Effects of general anesthesia combined with epidural anesthesia on the postoperative cognitive functions in pregnant women with dystocia were investigated. Postoperative cognitive functions of 84 dystocia pregnant women treated with cesarean section were retrospectively analyzed. Patients who received general anesthesia were included in group A (n=42), and those who received general anesthesia combined with epidural anesthesia were included in group B (n=42). Mean arterial pressure (MAP), heart rate (HR) and bispectral index (BIS) at different time-points after anesthesia in the two gro...
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