Forecasting the effectiveness of indoor residual spraying for reducing dengue burden
ConclusionsUsing a detailed agent-based dengue transmission model for Yucat án State, Mexico, we predict that high coverage indoor residual spraying (IRS) interventions can largely eliminate transmission for a few years, when applied a few months before the typical seasonal epidemic peak. However, vector control succeeds by preventing infections, which precludes natural im munization. Thus, as a population benefits from mosquito control, it gradually loses naturally acquired herd immunity, and the control effectiveness declines; this occurs across all of our modeled scenarios, and is consistent with other empirical work. Long term control that maintains early effectiv eness would require some combination of increasing investment, complementary interventions such as vaccination, and control programs across a broad region to diminish risk of importation.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Thomas J. Hladish Source Type: research
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