Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system.

Potential roles of reactive oxygen species derived from chemical substances involved in cancer development in the female reproductive system.
BMB Rep. 2018 Jun 20;:
Authors: Kim SM, Hwang KA, Choi KC
Abstract
Reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. While such oxidative stress conditions could be harmful to normal cells, they facilitate cancer cell growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. This review provides up to date findings regarding the role of ROS generation induced by diverse biological molecules and chemicals in representative women's' cancer. Specifically, we describe the cellular signaling pathways that regulate direct or indirect interactions between ROS homeostasis and metabolism within female genital cancer cells.
PMID: 29921411 [PubMed - as supplied by publisher]

Source: BMB Reports - June 20, 2018 Category: Biochemistry Authors: Kim SM, Hwang KA, Choi KC Tags: BMB Rep Source Type: research