Physical Training Prevents Depressive Symptoms And A Decrease In Brain-Derived Neurotrophic Factor In Parkinson's Disease.

Physical Training Prevents Depressive Symptoms And A Decrease In Brain-Derived Neurotrophic Factor In Parkinson's Disease. Brain Res Bull. 2014 Sep 25; Authors: Tuon T, Valvassori SS, Pont GC, Paganini CS, Pozzi BG, Luciano TF, Souza PS, Quevedo J, Souza CT, Pinho RA Abstract Depression is a neuropsychiatric disorder that is commonly found in patients with Parkinson's disease (PD). Many studies have suggested that physical exercise can have an antidepressant effect by increasing the levels of brain-derived neurotrophic factor (BDNF), and may also prevent neurodegenerative disease. However, different forms of training may promote different changes in the brain. The aim of this study was to investigate the effects of two types of physical training on depressive-like behavior, and on the levels of proBDNF, BDNF, and its receptor, TrkB, in a mouse model of PD. C57BL/6 mice were subjected to 60 days of exercise: either running on a treadmill or performing a strength exercise. PD was induced by striatal administration of 6-OHDA 24h after the last physical exercise session. Seven days after 6-OHDA injection, depressive-like behavior and apomorphine-induced rotational behavior were evaluated. The levels of proBDNF, BDNF, and TRKB were measured in the striatum and the hippocampus of mice by immunoblotting assay. The 6-OHDA-treated animals showed a significant increase in immobility time and rotational behavior compared with the control group....
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research