The Possibility of Developing Screening Criteria for Patients Suspected Multiple Myeloma (MM) at Thammasat University Hospital.

Conclusion: Among many factors those are the common presentation of MM, there were no factor or combination of factors that shown statistically significant to predict the diagnosis of multiple myeloma. However, we would suggest thinking of MM in elderly patients who have bone pain or osteoporosis, hypercalcemia, and azothemia or renal failure. PMID: 29926710 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - Category: General Medicine Tags: J Med Assoc Thai Source Type: research

Related Links:

Lactation is a unique period in which the maternal skeleton acts as a storehouse to provide substantial calcium to milk. Women who exclusively breastfeed lose an average of 210 mg of calcium per day, which doubles or triples with twins and triplets. Data from rodent and clinical studies are consistent with skeletal calcium being released to provide much of the calcium needed for milk production. This is programmed to occur independently of dietary calcium intake or intestinal calcium absorption, which remains at the prepregnant rate in breastfeeding women. After weaning, the skeleton is restored to its prior mineralization...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Lactation induces bone loss to provide sufficient calcium in the milk, a process that involves osteoclastic bone resorption but also osteocytes and perilacunar resorption. The exact mechanisms by which osteocytes contribute to bone loss remain elusive. Osteocytes express genes required in osteoclasts for bone resorption, including cathepsin K (Ctsk), and lactation elevates their expression. We show that Ctsk deletion in osteocytes prevented the increase in osteocyte lacunar area seen during lactation, as well as the effects of lactation to increase osteoclast numbers and decrease trabecular bone volume, cortical thickness,...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Contributors : Jennifer L Davis ; Linda Cox ; Christine Shao ; Cheng Lyu ; Shaopeng Liu ; Rajeev Aurora ; Deborah J VeisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStudies from global loss-of-function mutants suggest that alternative NF-kB downstream of NF-kB inducing kinase (NIK) is a cell-intrinsic negative regulator of osteogenesis. However, the interpretation of the osteoblast and/or osteocyte contribution to the bone phenotype is complicated by simultaneous osteoclast defects in these models. Therefore, we turned to a transgenic mouse model to investigate the direct role of N...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
This study compares the safety, pain level, and time involved in these techniques. Methods: We randomized 100 patients receiving ultrasound-guided unilateral thoracentesis in an academic medical center from December 2015 through September 2017 to either vacuum or manual drainage. Without using pleural manometry, the effusion was drained completely or until the development of refractory symptoms. Measurements included self-reported pain before and during the procedure (from 0 to 10), time for completion of drainage, and volume removed. Primary outcomes were rates of all-cause complications and of early termination of the...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
For those of your prescribing opioids, what percentage of your COT pts are on>90MME for chronic non cancer pain?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
We read with interest the article published by Arnold et  al1 examining the effect of timing of physical therapy (PT) for acute low back pain on health services utilization (HSU). Reducing overuse of imaging, opioids, injections, and surgery for low back pain is an international priority.2 That early access to PT could replace or reduce many of these ser vices is not an unreasonable proposition, and one that is worthy of rigorous scientific investigation. However, we feel that by emphasizing observational studies over randomized controlled trials in their synthesis of available literature, the authors have, in this ca...
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Departments Source Type: research
We would like to thank the authors of the Letter to the Editor for their interest and insight into our review, “The Impact of Timing of Physical Therapy for Acute Low Back Pain on Health Services Utilization.”1 We agree that to make more definitive causal claims about the outcomes from the timing of physical therapy, randomized control trials (RCTs) are needed. The final version of the abstract will refl ect a modification that removes causal claims. We believe that future research in this area should focus on using rigorous methodological designs that include randomization and observational studies that use la...
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Departments Source Type: research
Background: We aimed to evaluate the functional outcomes, incidence of bone tunnel laceration, and bone tunnel morphology of transosseous arthroscopic rotator cuff repair (ARCR) with the Arthro-TunnelerTM. Methods: Between May 2012 and April 2013, patients with full-thickness tears who underwent transosseous ARCR with the Arthro-TunnelerTM and could be followed for a minimum of 2 yr were included in this retrospective study. Functional outcomes, cuff repair integrity, intraoperative bone tunnel laceration, and postoperative bone tunnel morphology were analyzed. Results: We retrospectively evaluated 42 consec...
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
ConclusionSelective bowel resection algorithm provides a systematic approach in the surgical management of patients with bowel endometriosis. Adherence to the surgical plan according to the pre-operative imaging and criteria outlined in the algorithm can be accomplished in the majority of patients. The surgical team, however, should be aware that upstaging or downstaging may be required depending on the intra-operative findings. When feasible, the team should opt for a less extensive procedure to avoid complications associated with more radical surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusions In this pilot study of 23 asymptomatic women, intraurethral administration of lidocaine did not decrease VE compared with placebo. The lidocaine group had a greater percentage of interrupted flow patterns and increased electromyographic activity during micturition.
Source: Female Pelvic Medicine and Reconstructive Surgery - Category: OBGYN Tags: Original Articles Source Type: research
More News: Calcium | General Medicine | Laboratory Medicine | Myeloma | Orthopaedics | Osteoporosis | Pain | Renal Failure | Statistics | Study | Thailand Health