The Epigenome, Cell Cycle, and Development in Toxoplasma.

The Epigenome, Cell Cycle, and Development in Toxoplasma.
Annu Rev Microbiol. 2018 Jun 22;:
Authors: Kim K
Abstract
Toxoplasma gondii is a common veterinary and human pathogen that persists as latent bradyzoite forms within infected hosts. The ability of the parasite to interconvert between tachyzoite and bradyzoite is key for pathogenesis of toxoplasmosis, particularly in immunocompromised individuals. The transition between tachyzoites and bradyzoites is epigenetically regulated and coupled to the cell cycle. Recent epigenomic studies have begun to elucidate the chromatin states associated with developmental switches in T. gondii. Evidence is also emerging that AP2 transcription factors both activate and repress the bradyzoite developmental program. Further studies are needed to understand the mechanisms by which T. gondii transduces environmental signals to coordinate the epigenetic and transcriptional machinery that are responsible for tachyzoite-bradyzoite interconversion. Expected final online publication date for the Annual Review of Microbiology Volume 72 is September 8, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 29932347 [PubMed - as supplied by publisher]

Source: Annual Review of Microbiology - June 22, 2018 Category: Microbiology Authors: Kim K Tags: Annu Rev Microbiol Source Type: research