HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer

Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and metastatic form of PCa. In addition to androgen receptor (AR) signaling, neuroendocrine differentiation (NED) is associated with CRPC. Recent reports demonstrate that the downregulation of repressor element-1 silencing transcription factor (REST) protein is a key step in NED of PCa cells. Here, we report HOTAIR as a novel REST-repressed lncRNA that is upregulated in NED PCa cells and in CRPC.

Source: Cancer Letters - June 23, 2018 Category: Cancer & Oncology Authors: Yi-Ting Chang, Tzu-Ping Lin, Jui-Ting Tang, Mel Campbell, Yun-Li Luo, Shih-Yen Lu, Chia-Pei Yang, Ting-Yu Cheng, Ching-Hsin Chang, Tze-Tze Liu, Chi-Hung Lin, Hsing-Jein Kung, Chin-Chen Pan, Pei-Ching Chang Tags: Original Articles Source Type: research