Liver Radioembolization: An Analysis of Parameters that Influence the Catheter-Based Particle-Delivery via CFD.

Liver Radioembolization: An Analysis of Parameters that Influence the Catheter-Based Particle-Delivery via CFD. Curr Med Chem. 2018 Jun 22;: Authors: Aramburo J, Anton R, Rivas A, Ramos JC, Sangro B, Bilbao JI Abstract Radioembolization (RE) is a valuable treatment for liver cancer. It consists of administering radioactive microspheres via an intra-arterially placed catheter with the aim of lodging these microspheres, which are driven by the bloodstream, in the tumoral bed. Even though it is a safe treatment, some radiation-induced complications may arise. In trying to detect or solve the possible incidences that cause nontarget irradiation, simulating the particle-hemodynamics in hepatic arteries during RE via computational fluid dynamics (CFD) tools has become a valuable approach. This paper reviews the parameters that influence the outcome of RE that have been studied via numerical simulations. In this numerical approach, the outcome of RE is regarded as successful if particles reach the artery branches that feed tumor-bearing liver segments. Up to 10 parameters have been reviewed. The variation of each parameter actually alters the hemodynamics pattern in the vicinities of the catheter tip, and locally alters the incorporation of the particles into the bloodstream. Therefore, in general, the local influences of these parameters should result in global differences in terms of particle distribution in the hepatic artery branches. H...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research