Partial regeneration of uterine horns in rats through adipose-derived stem cell sheets.

Partial regeneration of uterine horns in rats through adipose-derived stem cell sheets. Biol Reprod. 2018 Jun 20;: Authors: Sun H, Lu J, Li B, Chen S, Xiao X, Wang J, Wang J, Wang X Abstract Severe uterine damage and infection lead to intrauterine adhesions, which result in hypomenorrhea, amenorrhea and infertility. Cell sheet engineering has shown great promise in clinical applications. Adipose-derived stem cells (ADSCs) are emerging as an alternative source of stem cells for cell-based therapies. In the present study, we investigated the feasibility of applying ADSCs as seed cells to form scaffold-free cell sheet. Data showed that ADSC sheets expressed higher levels of FGF, Col I, TGFβ and VEGF than ADSCs in suspension, while increased expression of this gene set was associated with stemness, including Nanog, Oct4 and Sox2. We then investigated the therapeutic effects of 3D ADSCs sheet on regeneration in a rat model. We found that ADSCs were mainly detected in the basal layer of the regenerating endometrium in the cell sheet group at 21 days after transplantation. Additionally, some ADSCs differentiated into stromal-like cells. Moreover, ADSC sheets transplanted into partially excised uteri promoted regeneration of the endometrium cells, muscle cells and stimulated angiogenesis, and also resulted in better pregnancy outcomes. Therefore, ADSC sheet therapy shows considerable promise as a new treatment for severe uterine damage. PMID: 29931041 ...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research

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AbstractThe first successful human heart transplantation was reported on 3 December 1967, by Christiaan Barnard in South Africa. Since then this life ‚Äźsaving procedure has been performed in over 120 000 patients. A limitation to the performance of this procedure is the availability of donor hearts with as many as 20% of patients dying before a donor's heart is available for transplant. Today, hearts for transplantation are procured from indiv iduals experiencing donation after brain death (DBD). Interestingly, this, however, was not always the case as the first heart transplants occurred after circulatory dea...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: REVIEW ARTICLE Source Type: research
Analyst, 2020, Accepted Manuscript DOI: 10.1039/C9AN02384D, PaperSung Joon Mo, Ju-Hyun Lee, Hyeon Gi Gye, Jong Min Lee, Eun-Joong Kim, Dongho Geum, Woong Sun, Bong Geun Chung We developed the microfluidic gradient device to utilize as a drug screening system with human induced pluripotent stem cell (iPSC)-derived motoneurons. The microfluidic channel was asymmetrically designed to generate the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsTransplanting kidneys from HCV-viremic donors into HCV-uninfected recipients increased quality-adjusted life expectancy and reduced costs compared with a strategy of transplanting kidneys from HCV-unexposed donors.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
BACKGROUND: Childhood abuse has a negative effect on mental health during pregnancy; however, the association between childhood abuse and suicide ideation has received relatively little attention. METHOD: Women at 28 weeks or more into their pregna...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Conditions:   Sleep;   Multiple Myeloma Interventions:   Behavioral: Mindfulness Awareness Practices for Insomnia;   Behavioral: Sleep Health Information Sponsor:   Medical College of Wisconsin Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionYounger age, earlier treatment within disease course, fewer cervical canal adhesions, and fewer surgical procedures improve reproductive outcome in patients with severe IUAs and amenorrhea.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: February 2018 Source:Journal of Minimally Invasive Gynecology, Volume 25, Issue 2 Author(s): Zaraq Khan, Jeffrey M. Goldberg In developed countries Asherman's syndrome is almost always the result of a prior intrauterine operative trauma. This is often asymptomatic but may result in hypo- or amenorrhea and can contribute to infertility and pregnancy complications. We review their etiology, clinical implications, and systems proposed to classify their extent. The numerous methods reported for performing lysis of intrauterine adhesions are summarized along with clinical results. Current strategies to preven...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 9 October 2017 Source:Journal of Minimally Invasive Gynecology Author(s): Zaraq Khan, Jeffrey M. Goldberg In developed countries, Asherman's Syndrome is almost always the result of a prior intrauterine operative trauma. This is often asymptomatic but may result in hypo- or amenorrhea and can contribute to infertility and pregnancy complications. We will review their etiology, clinical implications, and the systems which have been proposed to classify their extent. The numerous methods reported for performing lysis of intrauterine adhesions will be summarized along with the clinical resul...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
In developed countries Asherman's syndrome is almost always the result of a prior intrauterine operative trauma. This is often asymptomatic but may result in hypo- or amenorrhea and can contribute to infertility and pregnancy complications. We review their etiology, clinical implications, and systems proposed to classify their extent. The numerous methods reported for performing lysis of intrauterine adhesions are summarized along with clinical results. Current strategies to prevent recurrence of intrauterine adhesions have not been conclusively shown to be clinically effective, but the potential for endometrial regenerati...
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Special Article Source Type: research
Conclusion(s) Hysteroscopic adhesiolysis of IUAs is safe and effective in terms of reproductive outcome. The outcome is significantly affected by degree of intrauterine adhesions rather than the main complaint before the procedure.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
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