Novel haemodynamic structures in the human glomerulus.

NOVEL HAEMODYNAMIC STRUCTURES IN THE HUMAN GLOMERULUS. Am J Physiol Renal Physiol. 2018 Jun 20;: Authors: Neal CR, Arkill K, Bell JS, Betteridge KB, Bates DO, Winlove CP, Salmon AH, Harper SJ Abstract To investigate human glomerular structure under conditions of physiological perfusion we have analysed fresh and perfusion fixed normal human glomeruli at physiological hydrostatic and oncotic pressures using serial resin section reconstruction, confocal, multiphoton and electron microscope imaging. Afferent and efferent arterioles (21.5{plus minus}1.2µm and 15.9{plus minus}1.2µm diameter), recognised from vascular origins, lead into previously undescribed wider regions (43.2{plus minus}2.8 µm and 38.4{plus minus}4.9 µm diameter) we have termed vascular chambers (VCs) embedded in the mesangium of the vascular pole. Afferent VC(AVC) volume was 1.6 fold greater than Efferent VC(EVC) volume. From the AVC long non-branching high capacity conduit vessels (n=7) (Con; 15.9{plus minus}0.7µm diameter) led to the glomerular edge where branching was more frequent. Conduit vessels have fewer podocytes than filtration capillaries. VCs were confirmed in fixed and unfixed specimens with a layer of banded collagen identified in AVC walls by multiphoton and electron microscopy. Thirteen highly branched efferent first order vessels (E1;9.9{plus minus}0.4µm diam.) converge on the EVC draining into the efferent arteriole (15.9{plus minus}1.2µm diam....
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research