Helping Others Heal: Increasing the odds

Immune-building stem cell research works to increase the odds of lung transplants. Mayo Clinic research into stem cells for lung transplants and other types of transplants are increasing the odds of survival. In the 1970s, when?Cesar A. Keller, M.D., started his career in pulmonology, lung transplantation was widely considered science fiction. Now,?lung transplantation?is a lifesaving [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

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This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Modulation of the immune system using cellular therapy is seen as an increasingly attractive option to prevent solid organ graft rejection, while maintaining sufficient immune function to prevent many of the complications associated with general immunosuppression. We have previously demonstrated that murine myeloid progenitor cells (mMPC), cryopreserved after expansion in vitro, induce robust tolerance for matched organ grafts when preconditioning included lethal whole body irradiation and third party hematopoietic stem cell transplantation (HSC).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 73 Source Type: research
Organ transplant (Tx) recipients of non-European ancestry experience higher rejection rates. Stem cell research shows that single nucleotide variant mismatches (SNVMs) in mitochondria DNA (mtDNA) of the donor and host cells trigger alloimmune responses. However, no prior studies have addressed mtDNA SNVMs in organ transplantation. We hypothesized that SNVMs between donor-recipient (D-R) mtDNA sequences contribute to allograft immunogenicity. Our purpose was to conduct a proof-of-concept study examining the relationship between mtDNA SNVMs and immunogenicity in human thoracic Tx recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 156 Source Type: research
Pentraxin-3 (PTX3) polymorphisms influence the risk of invasive pulmonary aspergillosis (IPA) in chronic obstructive pulmonary disease patients, hematopoietic stem cell recipients and solid organs recipients. Therefore, we aimed to investigate this association in a large lung transplant population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 266 Source Type: research
Alveolar macrophages are key regulators of the innate immune response and participate in the stem cell niche to organise tissue repair and lung homeostasis. The fate of donor alveolar macrophages is poorly understood as existing studies have relied on sex chromosome labelling or HLA typing methodologies. We sought to confirm the existence of a long-lived pool of donor-derived alveolar macrophages using single cell RNA sequencing in sex mismatched lung transplant patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 365 Source Type: research
We present our protocol for perfusion of porcine lungs with human stem cells using our ex-vivo machine.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 452 Source Type: research
The endothelium has a pivotal role in the maintenance of cardiac function after heart transplantation, mainly by controlling the coronary circulation. Brain death (BD) as well as ischemia/reperfusion (IR) injury compromise vascular endothelium and thereby myocardial protection. Beneficial effects of conditioned medium (CM) from mesenchymal stem cells (MSCs) against IR injury have been demonstrated. We hypothesized that physiological saline supplemented CM could protect vascular grafts of BD rats from IR injury.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 432 Source Type: research
Late-onset noninfectious pulmonary complications (LONIPCs) after hematopoietic stem cell transplantation (HSCT) may occur within 2 years after HSCT. Its prognosis is still poor with a survival rate of less than 20 % at 5 years after its diagnosis, and early lung transplantation (LT) may be required in some cases. However, according to the current international guideline, the time interval between HSCT and LT must be more than 5 years for patients with a history of hematologic malignancy. It should be also noted that blood type may be changed at the time of HSCT, however, ABO-incompatible lung transplantation is contraindicated in general.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 537 Source Type: research
we investigated the effects of human amniotic fluid stem cells (hAFS) and rat adipose tissue stromal vascular fraction GFP-positive cells (rSVC-GFP) in a model of cardio-renal syndrome type II (CRSII).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 632 Source Type: research
Chronic pulmonary graft versus host disease (cpGvHD) is a diverse and underestimated complication following allogenic hematopoietic stem cell transplantation (alloHCT). We aimed to compare the airway architecture with chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1028 Source Type: research
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