Genomics and PBI: Tumor-Derived Target Amplification in Luminal B Patients and Implications for Therapy
Breast conserving surgery followed by postoperative breast irradiation is the treatment of choice for early stage breast cancers. Four phase III trials have demonstrated equal survival and non-inferior local tumor control with partial breast irradiation (PBI) in comparison to standard 5-6 week whole breast irradiation (WBI) in appropriately selected patients. Less favorable tumor biology is associated with higher local and systemic failures with all local therapy options. Current Next Generation Sequencing assays have empowered in-depth signatures of these cancers, providing hope for further customization of care.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Linda A. Smith, Robert R. Kuske Source Type: research