Inverse-Planned High Dose-Rate Interstitial Brachytherapy for Primary and Recurrent Squamous Cell Carcinomas of the Head and Neck

High dose-rate interstitial brachytherapy (HDRBT) at our institution has been limited to an extremely selected group of patients with heterogeneous head and neck (HN) cancers due to significant concerns for its toxicity profile. Our HDRBT technique in HN cancers differs from that of many other institutions in that our treatments are planned based on CT images and optimized using inverse planning simulated annealing (IPSA), which allows us to deliver higher doses per fraction than most reports in the literature.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research

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To report the feasibility and safety of Diffusing Alpha-emitter Radiation Therapy (DaRT), which entails the interstitial implantation of a novel alpha-emitting brachytherapy source, for the treatment of locally advanced and recurrent squamous cancers (SCC) of the skin and head and neck.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
The first clinical trial in humans with skin and oral cavity squamous cell carcinoma (SCC) was performed in order to evaluate the effect of a unique intratumoral alpha radiation-based tumor ablation treatment termed Diffusing Alpha emitters Radiation Therapy (DaRT).
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Yansong Liang, Xuemin Di, Zezhou Liu, Jinxin Zhao, Zeyang Wang, Jing Zhao, Aixia Sui, Hongtao Zhang, Juan WangJournal of Cancer Research and Therapeutics 2018 14(7):1660-1664 The skin squamous cell carcinoma (SCC) is a kind of malignancy of keratinocytes. SCC was originated within the epidermis or relevant appendages, which commonly occurred on sunlight exposure sites, such as the head and neck. This case report described an 85-year-old female patient with skin SCC at the right frontal, accompanied with skin ulcer. This patient suffered from indications that were not suitable for surgical resection, including old age, Alz...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Conclusions: With appropriate patient selection and choosing as lowest dose per fraction as possible, HDR brachytherapy with customized surface molds yields good oncological and cosmetic results for the treatment of localized skin BCC and SCC. PMID: 29789760 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
ConclusionsHPV‐related OPSCCs are associated with complete nodal response after 46 Gy of IMRT. Patients with full regional control (pN0) after IMRT and subsequent neck dissection show a significantly better overall survival, but smoking negatively interacts with this effect. Level of Evidence4 Laryngoscope, 2018
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
The tongue is the most common site of oral cavity cancer, the incidence of which has been found to be rapidly increasing. Patients with squamous cell carcinoma (SCC) of the tongue have a significantly worse prognosis than patients with other oral cavity and other head and neck cancers, because of the high rates of local recurrence following definitive treatment [1]. Early stage tongue SCC is treated by glossectomy or definitive radiotherapy including interstitial brachytherapy. For patients with locally advanced oral SCC, including tongue SCC, primary surgery is widely accepted as the standard treatment, and adjuvant concu...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Summary Radiation oncologists are increasingly tasked with the management of elderly patients with non‐melanoma skin cancer, unsuitable for surgical intervention due to inoperable lesions and/or poor performance status. In this cohort, hypofractionated radiotherapy, delivered either daily, alternative daily or once weekly is highly effective. A systematic literature search was conducted of PUBMED, MEDLINE and EMBASE databases using the algorithm (‘radiotherapy’ OR ‘radiation therapy’ OR ‘brachytherapy’) AND (‘hypofraction’ OR ‘hypofractionated’ OR ‘hypofra...
Source: Australasian Radiology - Category: Radiology Authors: Tags: Radiation Oncology —Review Article Source Type: research
This study focused on the pathologic characteristics of the patients with oral squamous cell carcinoma who underwent seed implantation after radical surgery, and the relationship of these characteristics with prognosis. Thus, 76 patients with oral squamous cell carcinoma, who were treated with surgery and subsequently with iodine 125 (125I) radioactive seed implantation, were recruited in this study. We summarized the demographic information, tumor size, location, clinical stage, prognosis, and pathologic characteristics, and discussed the correlations between prognosis and histologic features of oral squamous cell carcino...
Source: Technology in Cancer Research and Treatment - Category: Cancer & Oncology Authors: Tags: Technol Cancer Res Treat Source Type: research
Sensus Healthcare is a medical device company that focuses on providing non-invasive and cost-effective treatment of non-melanoma skin cancers and keloids utilizing superficial radiation technology (SRT). Their proprietary, FDA-cleared SRT technology...
Source: Medgadget - Category: Medical Devices Authors: Tags: Dermatology Exclusive Oncology Source Type: blogs
This study investigated the feasibility of using intraoperative directional brachytherapy for treatment of squamous cell carcinoma of the oropharynx. The patient had received a prior course of external beam therapy of 70 Gy in 2015. Due to positive margins near the carotid after the resection, and the increased risk of additional external radiation, brachytherapy was considered as a treatment option.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
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