Point-of-Care A1c Assay OK'd; Depo-Testosterone Generic; T1D'Vaccine'?
(MedPage Today) -- News and commentary from the endocrinology world
We present a brief overview of the potential prophylactic and treatment agents under investigation, some which could be initiated in the ED if proven effective.
Contributor : Johannes TextorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer vaccines utilizing naturally circulating dendritic cell (DC) subsets, such as plasmacutoid DCs (pDCs) and type 2 convential DCs (cDC2s), have demonstrated their potential as a therapy. For melanoma in recent clinical trials. These DC vaccines aim to. human. DC subsets on the. T cell transcriptional program, which. forms the. molecular. basis. of an. antitumor. T cell response, is. poorly understood. In. this study, we investigated the eraly gene expressionsignature of CD8+ T. cells following. stimulati...
Publication date: Available online 30 March 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Alan Stokes, Johanne Pion, Ornella Binazon, Benoit Laffont, Maude Bigras, Guillaume Dubois, Karine Blouin, Jamie K. Young, Michael A. Ringenberg, Nawel Ben Abdeljelil, Julius Haruna, Luis-Alexander Rodriguez
Publication date: Available online 30 March 2020Source: Journal of Genetics and GenomicsAuthor(s): Gang Liu, Haijuan Xiao, Linlin Liu, Lingyun Guo, Ruolan Guo, Xuyun Hu, Chanjuan Hao, Jingang Gui, Weiwei Jiao, Fang Xu, Adong Shen, Wei Li
Herpes zoster (HZ) results from reactivation of latent varicella zoster virus (VZV) presenting as a dermatomal rash. Diminished cellular immunity to VZV increases HZ risk and incidence in solid organ transplant (SOT) is higher than the general population. Immunogenicity and safety of the inactivated varicella vaccine (RZV, Shingrix) has been demonstrated in renal transplant (KT) but data in heart transplant (HT) are lacking.
In the past, Hepatitis B donors have been declined in patients who have not been vaccinated by the Hepatitis B vaccine. There is concern that these donors would transmit Hepatitis B to the recipient if they are not vaccinated. There is treatment available for these Hepatitis B infections, however, it has not been established as to its efficacy in patients on immunosuppression. In addition, hepatitis viruses have been reported to affect the endothelium of vital organs. Hepatitis B may injure the endothelium of the coronary vascular tree and could potentially result in a greater development of cardiac allograft vasculopathy ...
Herpes zoster, otherwise known as shingles, can be a devastating complication after heart transplantation due to persistent and severe herpetic neuralgia. Our heart transplant patients are recommended to have the shingles vaccine prior to heart transplantation, but this is not always achieved. We sought to assess whether the shingles vaccine did indeed prevent clinical shingles development after heart transplantation.
Emergent BioSolutions Inc. has inked another deal with fellow Gaithersburg biotech Novavax Inc. — this time, for its seasonal flu vaccine. The agreement means Emergent (NYSE: EBS) will develop and manufacture NanoFlu, the influenza vaccine which Novavax (NASDAQ: NVAX) successfully pushed through phase 3 clinical trials in a critical win announced March 24. It also comes just a few weeks aft er the two companies teamed up to get a COVID-19 vaccine to the clinic in the race against the pandemic.…
The Department of Health and Human Services outlined support for Moderna and Johnson &Johnson, as the companies work to develop coronavirus vaccines. Beefing up manufacturing capacity is a priority.(Image credit: David L. Ryan/Boston Globe via Getty Images)
Israel has begun testing a COVID-19 vaccine prototype on rodents at its bio-chemical defense laboratory, a source said on Tuesday.