Quantitative optical coherence tomography analysis of retinal degenerative changes in diabetic macular edema and neovascular age-related macular degeneration

Purpose: To investigate the relationship of the pre–anti-vascular endothelial growth factor (VEGF) retinal tissue area (RTA) and optical density (ODRT) of the retinal optical slice portion located in the central subfield, and their ratio (RTA/ODRT), in the presence of diabetic macular edema or of inraretinal cystic fluid in neovascular age-related macular degeneration, to central retinal thickness and best-corrected visual acuity after anti-VEGF treatment with ME resolution. Methods: The optical coherence tomography images and medical records of 33 patients (41 eyes) with neovascular age-related macular degeneration, 15 (21 eyes) with diabetic macular edema and 9 healthy individuals (15 eyes) were retrospectively analyzed. RTA, ODRT, and RTA/ODRT were calculated on pre–anti-VEGF B-scan images. Spearman rank correlation was used to assess the relationship of central retinal thickness and best-corrected visual acuity after anti-VEGF treatment with the variables under study. Results: Pre–anti-VEGF RTA was positively correlated with post–anti-VEGF central retinal thickness (ρ = 0.76; P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research