INFLAMMATORY CHOROIDAL NEOVASCULAR MEMBRANE: Long-Term Visual and Anatomical Outcomes After Intravitreal Anti–vascular Endothelial Growth Factor Therapy
Purpose: To assess the long-term visual and anatomical outcomes after intravitreal anti–vascular endothelial growth factor therapy for inflammatory choroidal neovascular membrane (CNVM). Methods: Retrospective case series of 15 consecutive cases of newly diagnosed inflammatory CNVM who were treated with intravitreal bevacizumab or ranibizumab injections. Results: The study included 8 women and 7 men with mean age at presentation with CNVM of 40.53 ± 17.46 years (range, 11–70 years), and mean follow-up duration after anti–vascular endothelial growth factor therapy was 20.53 ± 14.53 months (range, 6–48 months). All eyes had classic CNVM confirmed by fluorescein angiography, most commonly located in the peripapillary area (8 eyes, 53.3%), followed by juxtafoveal (4 eyes, 26.7%), and subfoveal location (3 eyes, 20%). All CNVMs showed complete resolution with mean 2.6 ± 1.2 injections per eye. Preinjection mean best-corrected visual acuity of logarithm of minimum angle of resolution 0.79 ± 0.76 (approximate Snellen equivalent 20/123) and mean central macular thickness of 435.9 ± 190.2 μm improved significantly to mean best-corrected visual acuity of logarithm of minimum angle of resolution 0.46 ± 0.43 (approximate Snellen equivalent 20/58) and mean central macular thickness of 262.13 ± 108.70 μm (P value 0.02 and
CONCLUSIONS: Post-resuscitation CAG with and without PCI are associated with better neurological recovery in patients with OHCA, regardless of primary electrocardiogram and patient age. PMID: 31526205 [PubMed - as supplied by publisher]
Publication date: October 2019Source: The Annals of Thoracic Surgery, Volume 108, Issue 4Author(s): Masashi Kawabori, Mishan Rambukwella, Alexander Yoon, Yong Zhan, Frederick Y. Chen, Gregory S. Couper
Conclusion: This case demonstrates that catheter-based treatment of submassive pulmonary embolism restores hemodynamic stability and thus is an alternative to surgery or systemic thrombolysis, even in the pediatric setting. While catheter-directed thrombolysis is a safe and effective alternative to systemic thrombolysis, further research is needed to establish appropriate dosing and indications in the adolescent population. PMID: 31528140 [PubMed]
Conclusion: Recurrent Takotsubo cardiomyopathy involving different anatomic regions of the left ventricle is a rare phenomenon yet appears to be similar to typical Takotsubo cardiomyopathy in presentation and hospital course. Chronic therapy with beta blockers and angiotensin-converting enzyme inhibitors did not prevent a recurrence in this patient, suggesting that optimum treatment needs to be determined. Takotsubo cardiomyopathy affecting different myocardial segments may recur in the same patient, implying that the adrenoceptor distribution theory needs further refinement. PMID: 31528138 [PubMed]
Endovascular therapy (EVT) is emerging as the primary treatment modality for peripheral vascular disease (PVD). Unfortunately, EVT has a limited success rate and high rate of reintervention. We investigated the association between hemodynamic changes, clinical improvement, and the need for re-intervention, after EVT for PVD.
A 67-year-old man with recurrent left lower lobe pneumonia and abscess was referred for a calcified lesion within the left chest, initially detected on non-contrast-enhanced computed tomography (CT) scan. CT angiography revealed an aneurysmal, aberrant left lower lobe pulmonary artery with scarred lung parenchyma (A). The aneurysm was bilobed with a 3.6-cm maximum diameter in the distal portion. In addition, the artery was aneurysmal at its origin from the descending thoracic aorta (A), just above the diaphragm.
Duplex ultrasound examination, computed tomography scans, and magnetic resonance angiography have traditionally been used as noninvasive methods to assess carotid stenosis severity. The degree of stenosis in asymptomatic patients has often been used as the main criterion to assess risk for plaque embolization and stroke. There has been an effort to find alternate methods to assess vulnerable plaques. This has included many modalities, including magnetic resonance imaging and other ultrasound techniques.
This study explores the safety and effect of acute cerebral infarction treatment by microcatheter injection of tirofiban combined with a Solitaire AB stent and/or stent implantation. Emergency cerebral angiograms showing the responsible vascular occlusion of 120 acute cerebral infarction patients who underwent emergency endovascular thrombectomy were included in the study. These patients were randomly divided into two groups using the random number table method: treatment group (n=60) that received thrombectomy (with cerebral artery stents) combined with intracerebral injection of tirofiban and control group (n=60) that on...
Nature Reviews Cardiology, Published online: 19 September 2019; doi:10.1038/s41569-019-0283-1In patients with STEMI and multivessel coronary artery disease, a strategy of revascularizing both the culprit lesion and any angiographically significant nonculprit lesions achieves better outcomes than a strategy of revascularizing only the culprit lesion.
ConclusionDue to the low incidence of abnormal origin of coronary artery among adults, this condition is often misdiagnosed as coronary artery spasm, resulting in delayed management. Lack of timely surgical intervention may lead to a poor prognosis.