Evaluation of patchy atrophy secondary to high myopia by semiautomated software for fundus autofluorescence analysis

Purpose: To evaluate the progression of patchy atrophy in high myopia using semiautomated software for fundus autofluorescence (FAF) analysis. Methods: The medical records and multimodal imaging of 21 consecutive highly myopic patients with macular chorioretinal patchy atrophy (PA) were retrospectively analyzed. All patients underwent repeated fundus autofluorescence and spectral domain optical coherence tomography over at least 12 months. Color fundus photography was also performed in a subset of patients. Total atrophy area was measured on FAF images using Region Finder semiautomated software embedded in Spectralis (Heidelberg Engineering, Heidelberg, Germany) at baseline and during follow-up visits. Region Finder was compared with manually measured PA on FAF images. Results: Twenty-two eyes of 21 patients (14 women, 7 men; mean age 62.8 + 13.0 years, range 32–84 years) were included. Mean PA area using Region Finder was 2.77 ± 2.91 SD mm2 at baseline, 3.12 ± 2.68 mm2 at Month 6, 3.43 ± 2.68 mm2 at Month 12, and 3.73 ± 2.74 mm2 at Month 18 (overall P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research